Department of Medicine
Faculty Profiles by Division

Department of Medicine

Faculty Profiles

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photo Vijay K. Yechoor, MD

Endocrinology and Metabolism

Professor of Medicine

Director, Diabetes and Beta Cell Biology Center

Diabetes and Metabolic Bone Disease Endowed Chair

Email: yechoorv@pitt.edu

Phone: 412-383-4251

Contact
Office: W1058 Biomedical Science Tower
200 Lothrop Street
Pittsburgh, PA 15213
 
Phone: 412-383-4251
Fax: 412-648-3290
E-mail: yechoorv@pitt.edu
Administrative Assistant:
Emily Welsh
Address: W1026 Biomedical Science Tower
200 Lothrop Street
Pittsburgh, PA 15213
Email: ejw74@pitt.edu
Phone: 412-648-9770
Fax: 412-648-3290
Education and Training
Education
MBBS, All India Institute of Medical Sciences, New Delhi, India, 1991
Training
Resident, Medicine, Baylor College of Medicine, 1995
Fellowship in Endocrinology, Diabetes & Metabolism, Longwood Fellowship Program, Joslin Diabetes Center, Harvard Medical School, 2002
Postdoctoral Fellow in Molecular & Cellular Biology, Baylor College of Medicine, 2003
Molecular Medicine Fellowship, Baylor College of Medicine, 2004
Research Interest
Dr. Yechoor’s research program focuses on developing targeted therapies that target beta cell mass and function in the pathogenesis of diabetes. He has a long record of external funding from the National Institutes of Health, the Veterans Administration, Juvenile Diabetes Research Foundation, and the American Diabetes Association. His currently funded projects include 1) the role of the circadian clock in beta cell stress adaptation, and 2) the role of Tead1 in the transcriptional regulation of quiescence and proliferation of beta cells. More recently, he has extended his research into adipose tissue and cardiac muscle biology.
Clinical Interest
Dr. Yechoor is an outstanding clinician and educator. He has more than 25 years of clinical experience treating patients in the fields of general internal medicine, endocrinology, diabetes, and metabolism.
Educational Interest
Dr. Yechoor has provided clinical and research mentorship to trainees at all levels and has taught didactic courses related to endocrinology, metabolism, translational biology, and molecular medicine. His national reputation in the field is exemplified by his numerous international speaking engagements and service on national and international grant review panels.
Publications
Selected Publications:
Aslanoglou, D., Bertera, S., Sánchez-Soto, M., Benjamin Free, R., Lee, J., Zong, W., Xue, X., Zong, W., Brissova, M., Logan, R.W., Wollheim, C.B., Trucco, M., Yechoor, V.K., Sibley, D.R., Bottino, R., Freyburg, Z. Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors. Transl Psychiatry. 2021; 11(1): 59.
Xiong, X., Lin, Y., Lee, J., Paul, A., Yechoor, V., Figueiro, M., Ma, K. Chronic circadian shift leads to adipose tissue inflammation and fibrosis. Mol Cell Endocrinol. 2021; 521: 111110.
Liu, R., Xiong, X., Nam, D., Yechoor, V., Ma, K. SRF-MRTF signaling suppresses brown adipocyte development by modulating TGF-ß/BMP pathway. Mol Cell Endocrinol. 2020; 515: 110920.
Liu, R., Jagannathan, R., Sun, L., Li, F., Yang, P., Lee, J., Negi, V., Perez-Garcia, E.M., Shiva, S., Yechoor, V.K., Moulik, M. Tead1 is essential for mitochondrial function in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2020; 319(1): H89-99.
Yin, H., Li, W., Chatterjee, S., Xiong, X., Saha, P., Yechoor, V., Ma, K. Metabolic-sensing of the skeletal muscle clock coordinates fuel oxidation. FASEB J. 2020; 34(5): 6613-6627.
Liu, H., Zhang, C.H., Ammanamanchi, N., Suresh, S., Lewarchik, C., Rao, K., Uys, G.M., Han, L., Abrial, M., Yimlamai, D., Ganapathy, B., Guillermier, C., Chen, N., Khaladkar, M., Spaethling, J., Eberwine, J.H., Kim, J., Walsh, S., Choudhury, S., et al. Control of cytokinesis by ß-adrenergic receptors indicates an approach for regulating cardiomyocyte endowment. Sci Transl Med. 2019; 11(512).
Chatterjee, S., Yin, H., Li, W., Lee, J., Yechoor, V.K., Ma, K. The Nuclear Receptor and Clock Repressor Rev-erba Suppresses Myogenesis. Sci Rep. 2019; 9(1): 4585.
Liu, R., Jagannathan, R., Li, F., Lee, J., Balasubramanyam, N., Kim, B.S., Yang, P., Yechoor, V.K., Moulik, M. Tead1 is required for perinatal cardiomyocyte proliferation. PLoS One. 2019; 14(2): e0212017.
Lee, J., Ma, K., Moulik, M., Yechoor, V. Untimely oxidative stress in ß-cells leads to diabetes - Role of circadian clock in ß-cell function. Free Radic Biol Me. 2018; 119: 69-74.
Gao, H., Ho, E., Balakrishnan, M., Yechoor, V., Yallampalli, C. Decreased insulin secretion in pregnant rats fed a low protein diet. Biol Reprod. 2017; 97(4): 627-635.
Sponsored Research/Activities
Title: Circadian Clock and Beta Cell Stress Adaptation
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK097160
Start Year: 2018
End Year: 2019
Title: Overcoming Insulin Deficiency and Resistance to Reduce Diabetes Risk
Role: Principal Investigator
Funding Agency: Pittsburgh Foundation
Grant Number: RES
Start Year: 2018
End Year: 2019
Title: Overcoming Insulin Deficiency and Resistance to Reduce Diabetes Risk
Role: Co-Investigator
Funding Agency: Pittsburgh Foundation
Grant Number: RES
Start Year: 2020
End Year: 2021
Notable Achievements
Best Teacher Award, Division of Diabetes, Endocrinology & Metabolism, Baylor College of Medicine, 2015