Department of Medicine
Faculty Profiles by Division

Department of Medicine

Faculty Profiles

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photo Lianghui Zhang, MD, PhD

Pulmonary, Allergy and Critical Care Medicine

Assistant Professor of Medicine


Phone: 412-692-2211

Office: UPMC Montefiore, NW628
3459 Fifth Avenue
Pittsburgh, PA 15213
Phone: 412-692-2211
Fax: 412-692-2260
Administrative Assistant:
Shannon McKenzie
Phone: 412-692-2211
Fax: 412-692-2260
Education and Training
MD, Medical School of Fudan University, Shanghai, China, 2003
PhD; Pharmacology, University of Rochester, NY, 2013
Postdoctoral, University of Illinois at Chicago, 2022
Research Interest
My laboratory studies lung vascular biology and immuno-pathogenesis of acute lung injury. Our research focuses on the mechanism of respiratory viral-induced lung vascular injury and signals between endothelial cells and immune cells during the innate and adaptive immune response. The SARS-CoV-2 and H1N1-induced acute lung injury models are two major animal models used in the laboratory. We are also interested in lung vascular regeneration and mechanisms of transcriptional regulation in the vasculature. By understanding the mechanisms which regulate the balance between inflammatory injury and regeneration in viral acute lung injury, we will be able to develop new therapies that minimize inflammatory injury, maximize tissue repair and reduce patient mortality.
Clinical Interest
Developing novel strategies to minimize inflammatory lung injury, maximize lung repair and reduce patient mortality.
Educational Interest
Mentoring and training graduate students to be next generation of scientists in lung injury, vascular biology and immunology.
For my complete bibliography, Click Here.
Selected Publications:
Zhang L, Gao S, White Z, Dai Y, Malik AB, Rehman J. Single-Cell Transcriptomic Profiling Identifies Dynamic Inflammatory and Regenerative Subpopulations Following Vascular Injury. JCI Insight. 2022; Jun 8;7(11): e158079.
Zhang L, Dutta S, Xiong S, Chan M, Chan KK, Fan TM, Bailey KL, Lindeblad M, Cooper LM, Rong L, Gugliuzza AF, Shukla D, Procko E, Rehman J, Malik AB. An engineered high affinity ACE2 peptide therapeutically mitigates lung vascular injury and mortality induced by distinct SARS-CoV-2 variants. Nature Chemical Biology. 2022; 2022 Mar;18(3): 342-351.
Zhang L, Narayanan KK, Cooper L, Chan KK, Devlin CA, Aguhob A, Shirley K, Rong L, Rehman J, Malik AB, Procko E. An engineered ACE2 decoy receptor can be administered by inhalation and potently targets the BA.1 and BA.2 omicron variants of SARS-CoV-2. bioRxiv. 2022; Mar 28:2022: Preprint.
Xiong S, Zhang L, Richner JM, Class J, Rehman J, Malik AB. Interleukin-1RA Mitigates SARS-CoV-2-Induced Inflammatory Lung Vascular Leakage and Mortality in Humanized K18-hACE-2 Mice. Arterioscler Thromb Vasc Biol. 2021; Nov;41(11): 2773-2785.
Jambusaria A, Hong Z, Zhang L, Srivastava S, Jana A, Toth PT, Dai Y, Malik AB, Rehman J. Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammation. Elife. 2020; Jan 16;9: doi:10.7554/eLife.51413.
Liu M, Zhang L, Marsboom G, Jambusaria A, Xiong S, Toth PT, Benevolenskaya EV, Rehman J, Malik AB. Sox17 is required for endothelial regeneration following inflammation-induced vascular injury. Nat Communications. 2019; May 9;10(1): 2126.
Zhang L, Jambusaria A, Hong Z, Marsboom G, Toth PT, Herbert BS, Malik AB, Rehman J. SOX17 Regulates Conversion of Human Fibroblasts Into Endothelial Cells and Erythroblasts by Dedifferentiation Into CD34+ Progenitor Cells. Circulation. 2017; Jun 20;135(25): 2505-2523.
Zhang L, Malik AB, Rehman J. Reprogramming fibroblasts to endothelial cells: converted or born again?. Circulation. 2014; Sep 30;130(14): 1136-8.
Zhang L, Malik S, Pang J, Wang H, Park KM, Yule DI, Blaxall BC, Smrcka AV. Phospholipase Ce hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy. Cell. 2013; Mar 28;153(1): 216-27.
Zhang L, Malik S, Pang J, Wang H, Park KM, Yule DI, Blaxall BC, Smrcka AV. Phospholipase Ce hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy. Cell. 2013; 153(1): 216-27.
Notable Achievements
The Finalist for the 2021 Cournand & Comroe Early Career Investigator Award, 2021
The Winner of American Heart Association - 3 CPR Shark Tank Research Competition, 2018