Department of Medicine
Faculty Profiles by Division

Division of Gastroenterology, Hepatology and Nutrition

Faculty Profiles

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photo Randall E. Brand, MD


Professor of Medicine

Academic Director, GI-Division, UPMC Shadyside

Director, GI Malignancy Early Detection, Diagnosis & Prevention Program


Phone: 412-623-3105

Office: Division of Gastroenterology, Hepatology & Nutrition @ Shadyside
5200 Centre Avenue, Suite 409
Pittsburgh, PA 15232
Phone: 412-623-3105
Fax: 412-623-3106
Administrative Assistant:
Clinical-Procedure Scheduling
Address: 5200 Center Avenue, Suite 409
Pittsburgh, PA 15232
Phone: 412-623-3115
Fax: 412-623-3106
Education and Training
MD, University of Michigan / Ann Arbor, 1987
BS, University of Michigan / Ann Arbor, 1983
Gastroenterology Fellowship - Clinical Track, University of California / San Francisco, 1993
Residency - Internal Medicine, University of Michigan / Ann Arbor, 1990
Internship - Internal Medicine, University of Michigan / Ann Arbor, 1988
Research Interest
Dr. Brand is a Professor of Medicine and a physician-scientist with an extensive background in pancreatic diseases mainly focused on the early diagnosis of pancreatic cancer and cystic lesions of the pancreas. He also has research interests involving familial pancreatic cancer and other hereditary GI disorders. He is leader of the University of Pittsburgh’s Pancreatic Adenocarcinoma Gene-Environment Registry (PAGER). The biospecimen repository developed as part of the PAGER study is nationally recognized and serves as an excellent resource for multiple NIH/NCI funded projects along with national and international collaborations with outside researchers. He is a key contributor to the Early Detection Research Network, especially in research related to pancreatic cancer and cystic neoplasms and is currently funded in the network as a principal investigator to lead both a multi-center Pancreatic Cancer Clinical Validation Center and Biomarker Developmental Laboratory.
Clinical Interest
Dr. Brand's clinical practice focuses on the management of pancreatic cancer, cystic lesions of the pancreas and patients with other gastrointestinal (GI) cancers. As director of the Hereditary GI Tumor Program, Dr. Brand specializes in the management of individuals at high risk for the development of colon cancer,pancreatic cancer and other GI malignancies. Dr. Brand works closely with Genetic counselors who have an expertise in the evaluation individuals with a GI cancer predisposition based on personal and family history.
For my complete bibliography, Click Here.
Selected Publications:
Lynch, H.T., Brand, R.E., Lynch, J.F., Fusaro, R.M., Kern, S.E. Hereditary factors in pancreatic cancer. Journal of hepato-biliary-pancreatic surgery. 2002; 9(1): 12-31.
Lynch, H.T, Deters, C.A, Lynch, J.F, Brand, R.E. Familial pancreatic carcinoma in Jews. Familial Cancer. 2004; 3(3-4): 233-40.
Lynch, H.T., Deters, C.A., Synder, C.L., Lynch, J.F., Villeneuve, P., Silberstein, J., Martin, H., Narod, S.A., Brand, R.E. BRCA1 and pancreatic cancer: pedigree findings and their causal relationships. Cancer genetics and cytogenetics. 2005; 158(2): 119-25.
Brand, R.E., Lynch, H.T. Genotype/phenotype of familial pancreatic cancer. Endocrinology and metabolism clinics of North America. 2006; 35(2): 405-15.
Uttam, S., Bista, R.K., Staton, K., Alexandrove, S., Choi, S., Bakkenist, C.J., Hartman, D.J., Brand, R.E., Liu, Y. Investigation of depth-resolved nanoscale structural changes in regulated cell proliferation and chromatin decondensation. Biomedical optics express. 2013; 4(4): 596-613.
Brand, H., Diergaarde, B., O'Connell M.R., Whitcomb, D.C., Brand, R.E. Variation in the y-glutamyltransferase 1 gene and risk of chronic pancreatitis. Pancreas. 2013; 42(5): 836-40.
Stan, S.D., Singh, S.V., Whitcomb, D.C., Brand, R.E. Phenethyl isothiocyanate inhibits proliferation and induces apoptosis in pancreatic cancer cells in vitro and in a MIAPaca2 xenograft animal model. Nutrition and cancer. 2014; 66(4): 747-55.
Hartman, D.J., Krasinskas, A.M., Uttam, S., Staton, K., Bista, R., Rizvi, S., Slivka, A., Brand, R., Liu, Y. Assessment of nuclear nanomorphology marker to improve the detection of malignancy from bile duct biopsy specimens. American journal of clinical pathology. 2014; 141(6): 884-91.
Brand, R.E. Decade in review-pancreatic diseases: advances in understanding and care of pancreatic diseases. Nature reviews. Gastroenterology & hepatology. 2014; 11(11): 650-2.
Wilcox, C.M., Yadav, D., Ye, T., Gardner T.B., Gelrud, A., Sandhu, B.S., Lewis, M.D., Al-Kaade S., Cote, G.A., Forsmark, C.E., Guda, N.M., Conwell, D.L., Banks, P.A., Muniraj, T., Romagnuolo, J., Brand, R.E., Slivka, A., Sherman, S., Wisniewski, S.R., Whitcomb, D.C. Chronic pancreatitis pain pattern and severity are independent of abdominal imaging findings. Clinical gastroenterology and hepatology: the official clinical practice journal. 2015; 13(3): 552-60.
Sponsored Research/Activities
Title: Internal development of Freenome’s early cancer screening platform technology
Role: Principal Investigator
Funding Agency: Freenome, Inc.
Grant Number: IND AGR
Start Year: 2020
End Year: 2021
Title: Adaptive Prospective Study for the Early Detection of Pancreatic Cancer (PDAC) in High Risk Groups
Role: Principal Investigator
Funding Agency: Immunovia
Grant Number: RES
Start Year: 2017
End Year: 2022
Title: Retrospective Study for the Early Detection of Pancreatic Cancer
Role: Principal Investigator
Funding Agency: Immunex Corporation
Start Year: 2017
End Year: 2022
Title: Cell-Free DNA as a Potential Biomarker for Pancreatic Cancer
Role: Principal Investigator
Funding Agency: Freenome, Inc.
Grant Number: RES
Start Year: 2017
End Year: 2020
Title: Assess Colonic Inflammation Regulatory Pathways in Healthy Donors and Crohn's Disease Patients: Collaborative Program with University of Pittsburgh and Takeda California
Role: Co-Investigator
Funding Agency: Takeda Pharmaceuticals, Inc.
Start Year: 2018
End Year: 2021
Title: Non-invasive Imaging of Pancreatic Ductal Adenocarcinoma at Early/Precursor Stage
Role: Co-Investigator
Funding Agency: American Cancer Society
Start Year: 2017
End Year: 2021
Title: Consortium for the Study of Pancreatitis: Pittsburgh Clinical Center
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: U01 DK108306
Start Year: 2015
End Year: 2020
Notable Achievements
Named to “Pittsburgh Magazine Top Doctors”, Pittsburgh Magazine, 2012-2022
Named to “Best Doctors” for specialty in Gastroenterology, Best Doctors, Inc., 2010-2022
Recipient of the First Annual Moore Memorial Award for Pancreatic Cancer Research, National Hirschberg Foundation, 2011
Excellence in Healthcare Honoree, National Pancreas Foundation, 2019