Department of Medicine
Faculty Profiles by Division

Division of Gastroenterology, Hepatology and Nutrition

Faculty Profiles

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photo Richard H. Duerr, MD


Professor of Medicine, Human Genetics, and Clinical and Translational Science

Inflammatory Bowel Disease Genetic Research Endowed Chair

Co-Director and Scientific Director, UPMC Inflammatory Bowel Disease Center

Professor of Medicine, Human Genetics, and Clinical and Translational Science


Phone: 412-648-9497

Office: Room : BSTWR-S704, Biomedical Science Tower South
200 Lothrop Street
Pittsburgh, PA 15261
Phone: 412-648-9497
Administrative Assistant:
Academic Scheduling
Address: Div. of GI, Hep & Nutr - MAB, 4th Fl
3708 Fifth Ave
Pittsburgh, PA 15213
Phone: 412-578-9515
Fax: 412-578-9537
Education and Training
BS, University of Minnesota - Duluth, 1979
MD, University of Minnesota, 1983
Training Program in Internal Medicine, University of California at San Francisco, 1986
Integrated Training Program in Digestive Diseases, University of California at Los Angeles, 1990
Research Interest
Dr. Duerr holds the Inflammatory Bowel Disease Genetic Research Chair and is a Professor of Medicine, Human Genetics, and Clinical and Translational Science at the University of Pittsburgh. He is Co-Director and Scientific Director of the University of Pittsburgh Medical Center Inflammatory Bowel Disease Center and has been involved in research related to inflammatory bowel disease throughout his career.

He serves on the Management Committee of the International IBD Genetics Consortium, participates in the Gut Cell Atlas initiative funded by the The Leona M and Harry B Helmsley Charitable Trust, and is the Associate Chief Scientist for Translational Research on the Leadership Team for the Crohn's & Colitis Foundation's IBD Plexus research and information exchange platform. His research program has had uninterrupted funding from the NIH, the Crohn's & Colitis Foundation, and other foundations since 1995.

Dr. Duerr is a member of the American Gastroenterological Association, American Society of Human Genetics, and Crohn's & Colitis Foundation. He has been an invited lecturer in local, national and international venues, and he has published original inflammatory bowel disease genetics research articles in journals such as Nature, Science, Nature Genetics, American Journal of Human Genetics, and Human Molecular Genetics. He has served on grants review committees for the NIH and Crohn's & Colitis Foundation.
Clinical Interest
Inflammatory Bowel Disease
For my complete bibliography, Click Here.
Selected Publications:
Huang, H., Fang, M., Jostins, L., Umicevic Mirkov, M., Boucher, G., Anderson, C.A., Andersen, V., Cleynen, I., Cortes, A., Crins, F., D'Amato, M., ..., Duerr, R.H., Mathew, C.G., Rioux, J.D., McGovern, D.P.B., Cho, J.H., Georges, M., Daly, M.J., Barrett, J.C. Fine-mapping inflammatory bowel disease loci to single-variant resolution. Nature. 2017; 547(7662): 173-178.
Li, D., Achkar, J.P., Haritunians, T., Jacobs, J.P., Hui, K.Y., D'Amato, M., Brand, S., Radford-Smith, G., Halfvarson, J., Niess, J.H., Kugathasan, S., Buning, C., Schumm, L.P., Klei, L., Ananthakrishnan, A., Aumais, G., ..., Braun, J., McGovern, D.P., Duerr, R.H. A pleiotropic missense variant in SLC39A8 is associated with Crohn's disease and human gut microbiome composition. Gastroenterology. 2016; 151(4): 724-32.
Chuang, L.S., Villaverde, N., Hui, K.Y., Mortha, A., Rahman, A., Levine, A.P., Haritunians, T., Ng, S.M., Zhang, W., Hsu, N.Y., Facey, J.A., Luong, T., Fernandez-Hernandez, H., Li, D., ..., Duerr, R.H., Merad, M., McGovern, D.P., Peter, I., Cho, J.H. A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GMCSF. Gastroenterology. 2016; 151(4): 710-723.
Cleynen, I., Boucher, G., Jostins, L., Schumm, L.P., Zeissig, S., Ahmad, T., Andersen, V., Andrews, J.M., Annese, V., Brand, S., Brant, S.R., Cho, J.H., Daly, M.J., Dubinsky, M., Duerr, R.H., ..., Radford-Smith, G., McGovern, D.P., Barrett, J.C., Lees, C.W. Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study. Lancet. 2016; 387(10014): 156-67.
Adamik, J., Henkel, M., Ray, A., Auron, P.E., Duerr, R., Barrie, A. The IL17A and IL17F loci have divergent histone modifications and are differentially regulated by prostaglandin E2 in Th17 cells. Cytokine. 2013; 64(1): 404-12.
Jostins, L., Ripke, S., Weersma, R.K., Duerr, R.H., McGovern, D.P., Hui, K.Y., Lee, J.C., Schumm, L.P., Sharma, Y., Anderson, C.A., Essers, J., Mitrovic, M., Ning, K., Cleynen, I., Theatre, E., Spain, S.L., Raychaudhuri, S., ..., Barrett, J.C., Cho, J.H. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature. 2012; 491(7422): 119-24.
Achkar, J.P., Klei, L., de Bakker, P.I., Bellone, G., Rebert, N., Scott, R., Lu, Y., Reguiero, M., Brzezinski, A., Kamboh, M.I., Fiocchi, C., Devlin, B., Trucco, M., Ringquist, S., Roeder, K., Duerr, R.H. Amino acid position 11 of HLA-DRB1 is a major determinant of chromosome 6p association with ulcerative colitis. Genes and Immunity. 2012; 13(3): 245-52.
Silverberg, M.S., Cho, J.H., Rioux, J.D., McGovern, D.P., Wu, J., Annese, V., Achkar, J.P., Goyette, P., Scott, R., Xu, W., Barmada, M.M., Klei, L., Daly, M.J., Abraham, C., Bayless, T.M., Bossa, F., Griffiths, A.M., ..., Roeder, K., Duerr, R.H. Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. Nature Genetics. 2009; 41(6): 216-20.
Silverberg, M.S., Duerr, R.H., Brant, S.R., Bromfield, G., Datta, L.W., Jani, N., Kane, S.V., Rotter, J.I., Schumm, P.L., Steinhart, H.A., Taylor, K.D., Yang, H., Cho, J.H., Rioux, J.D., Daly, M.J., NIDDK IBD Genetics Consortium. Refined genomic localization and ethnic differences observed for the IBD5 association with Crohn's disease. European Journal of Human Genetics. 2007; 15(3): 328-35.
Duerr, R.H., Taylor, K.D., Brant, S.R., Rioux, J.D., Silverberg, M.S., Daly, M.J., Steinhart, A.H., Abraham, C., Regueiro, M., Griffiths, A., Dassopoulos, T., Bitton, A., Yang, H., Targan, S., Datta, L.W., Kistner, E.O., Schumm, L.P., ..., Nicolae, D.L., Cho, JH. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science. 2006; 314(5804): 1461-3.
Sponsored Research/Activities
Title: Single Cell Multimodal Omics Analysis of Colonoscopic Biopsy-Derived Immune Cells in Crohn's Disease
Role: Principal Investigator
Funding Agency: The Helmsley Charitable Trust
Grant Number: RES
Start Year: 2022
End Year: 2024
Title: NIDDK IBD Genetics Consortium Genetic Research Center
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: U01 DK062420
Start Year: 2017
End Year: 2022
Title: Study of a Prospective Adult Research Cohort with Inflammatory Bowel Disease (SPARC IBD)
Role: Principal Investigator
Funding Agency: Crohns & Colitis Foundation
Grant Number: RES
Start Year: 2017
End Year: 2021
Title: IBD Plexus
Role: Co-Investigator
Funding Agency: Crohns & Colitis Foundation
Start Year: 2015
End Year: 2021
Notable Achievements
Crohn's & Colitis Foundation IBD Plexus Associate Chief Scientist, Translational Research, 2015 - Present
Crohn's & Colitis Foundation IBD Plexus Integration and Transition Team Member, 2014 - 2015
Inflammatory Bowel Disease Genetic Research Chair, 2011 - Present
Ad Hoc member of Genetics of Health and Disease NIH Study Section and NIH Special Emphasis Panels, 2008, 2009, 2012, 2016
Member, American Society of Human Genetics, 2003 - Present
Principal Investigator of NIDDK IBD Genetic Consortium Genetic Research Center, 2002 - Present
Editor, Genetics Section, Inflammatory Bowel Diseases, 2002-2006, 2008 – 2011
Physician of the Year, Crohn’s & Colitis Foundation, Western Pennsylvania/West Virginia Chapter, 2000
Crohn’s & Colitis Foundation Grants Review Committee, 1996 -1999, 2009 - 2011
Member, American Gastroenterological Association, 1992 - Present