Department of Medicine
Faculty Profiles by Division

Division of Gastroenterology, Hepatology and Nutrition

Faculty Profiles

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photo Michael A. Pezzone, MD, PhD

Associate Professor of Medicine and Pharmacology & Chemical Biology

Director of Gastroenterology, UPMC Mercy

Email: pezzone@pitt.edu

Phone: 412-232-8888

Contact
Office: 1515 Locust St.
5th Floor
Pittsburgh, PA 15219
 
Phone: 412-232-8888
Fax: 412-232-8887
E-mail: pezzone@pitt.edu
Education and Training
Education
MD, PhD in Neuroimmunology and Stress, University of Pittsburgh, 1994
AB (Chemistry and Biochemistry), Cornell University, 1987
Training
Internship in Internal Medicine, University of Pittsburgh, 1995
Residency in Internal Medicine, University of Pittsburgh, 1997
Fellowship in Gastroenterology, University of Pittsburgh, 2000
Research Interest
Dr. Pezzone collaborates currently with Dr. Steven Badylak at the McGowan Institute for Regenerative Medicine to investigate the cytokine response to extracellular matrix (ECM) and determination of the phenotype of immune cells in fixed specimens from patients with ulcerative colitis.

Additional research interests include: Macrophage phenotype modulation in tissue regeneration and down regulation of inflammation, the role of glial cells and the peripheral nervous system in the development of malignancy in chronic inflammatory states, modulation of mast cells and their role in visceral pain, neuromodulation of pain, development of pain biomarkers, and visceral afferents in the gastrointestinal and urinary tracts and their role in visceral hyperalgesia.
Clinical Interest
Dr. Pezzone directs patient gastroenterology services for UPMC Mercy. He has extensive experience in the diagnosis and treatment of all gastroenterology diseases.
Educational Interest
Dr. Pezzone is committed to the education of gastroenterology resident and fellow trainees.
Publications
Selected Publications:
Mupparapu SK, Pezzone MA. A Rare Case of Dual Cecae. ACG Case Rep J. 2015; 2(2): 76.
Silos-Santiago I, Hanning G, Eutamene H, Ustinova EE, Bernier SG, Ge P, Graul C, Jacobson S, Jin H, Liong E, Kessler MM, Reza T, Rivers S, Shea C, Tchernychev B, Bryant AP, Kurtz CB, Bueno L, Pezzone MA, Currie MG. Gastrointestinal Pain: Unraveling a Novel Endogenous Pathway through Uroguanylin/Guanylate Cyclase-C/cGMP Activation. Pain. 2013; 154(9): 1820-30.
Fitzgerald JJ, Usinova E, KoronowskiKB, deGroat WC, Pezzone MA. Evidence for the Role of Mast Cells in Colon-Bladder Cross Organ Sensitization. Auton Neurosci. 2013; 173(1-2): 6-13.
Turner NJ, Pezzone MA, Brown BN, Badylak SF. Quantitative Multispectral Imaging of Herovici's Polychrome for the Assessment of Collagen Content and Tissue Remodeling. J Tissue Eng Regen Med. 2013; 7(2): 139-48.
Ustinova EE, Fraser MO, Pezzone MA. Cross-Talk and Sensitization of Bladder Afferent Nerves. Neurourol Urodyn. 2010; 29(1): 77-81.
Bakdash S, Lyons JM, Bastacky SI, Pezzone MA, McGee JB, Schoen RE, Regueiro M, Lee KK, Bontempo FA. Management of Persistent Gastric Bleeding in a Patient with Glanzmann's Thrombasthenia. Am J Hematol. 2008; 83(5): 411-5.
Liang R, UstinovaEE, Patnam R, Fraser MO, Gutkin DW, Pezzone MA. Enhanced Expression of Mast Cell Growth Factor and Mast Cell Activation in the Bladder Following the Resolution of Trinitrobenzenesulfonic Acid (TNBS) Colitis in Female Rats. Neurourol Urodyn. 2007; 26(6): 887-93.
Christianson JA, Liang R, Usinova EE, Davis BM, Fraser MO, Pezzone MA. Convergence of Bladder and Colon Sensory Innervation Occurs at the Primary Afferent Level. Pain. 2007; 128(3): 235-43.
Ustinova EE, Gutkin DW, Pezzone MA. Sensitizationo f Pelvic nerve Afferents and Mast Cell Infiltration in the Urinary Bladder Following Chronic Colonic Irritation is Mediated by Neuropeptides. Am J Physiol Renal Physiol. 2007; 292(1): 123-30.
Ustinova EE, Fraser MO, Pezzone MA. Colonic Irritation int he Rat Sensitizes urinary Bladder Afferents to Mechanical and Chemical Stimuli: An Afferent Origin of Pelvic Organ Cross-Sensitization. Am J Physiol Renal Physiol. 2006; 290(6): F1478-87.
Notable Achievements
Fellow, American Gastroenterological Association, 2010 to present
Castle Connolly Top Doctor, 2008 to present
Top Doctor in Gastroenterology in Lake/Sumter, FL,, 2019 to present
Pittsburgh Magazine Top Doctor, 2008-11
Visiting Scholar, The First Affiliated Hospital of Nanchang University, Nanchang City, Jiangxi, China, 2016
UPMC Recognition for Service Excellence “Above and Beyond”, 2007
Audrey Love Charitable Foundation Award for Research in IBS, 2007