Department of Medicine
Faculty Profiles by Division
Select a Division
Cardiology
Endocrinology and Metabolism
Gastroenterology, Hepatology and Nutrition
General Internal Medicine
Geriatric Medicine
Hematology/Oncology
Infectious Diseases
Pulmonary, Allergy and Critical Care Medicine
Renal-Electrolyte
Rheumatology and Clinical Immunology
ALL DEPARTMENT FACULTY
Division of Hematology/Oncology
Faculty Profiles
[
Return To Index page
]
Samit Ghosh, PhD
Hematology/Oncology
Assistant Professor of Medicine
Email:
sag130@pitt.edu
Phone: 412-624-4574
Contact
Office:
W1062 Biomedical Science Tower (BST)
200 Lothrop St
Pittsburgh, PA 15261
Phone:
412-624-4574
Fax:
412-648-5980
E-mail:
sag130@pitt.edu
Education and Training
Education
PhD, Chittaranjan National Cancer Institute, Jadavpur University, India, 2005
MSc, University of Burdwan, India, 1999
Training
Research Assistant Professor, University of Pittsburgh, Pittsburgh, PA, 2015
Research Associate, University of Pittsburgh, Pittsburgh, PA, 2013
Postdoctoral Fellowship, Emory University, Atlanta, GA, 2008
Postdoctoral Associate, University of Texas Health Science Center at Tyler, TX, 2005
Research Interest
Sickle Cell Disease (SCD) is one of the most common rare genetic disorders affecting 20-25 million people worldwide with progressive multiorgan complications leading to early mortality. The kidney is one of the most severely affected organs in SCD. Dr. Ghosh’s research aims to delineate the cellular and molecular mechanisms of kidney diseases, ranging from acute kidney injury (AKI) to chronic kidney disease (CKD) and end-stage renal disease (ESRD). His research involves two major components. One is to determine the role of circulating hemolytic byproducts, such as, heme and its scavenger proteins, hemopexin and alpha-1-microglobulin, promoting development of AKI. The other is to delineate the role of renal microvascular endothelium and tubular epithelium instigating AKI-to-CKD transition in SCD. His research interests also include the pathophysiological interactions of kidney injuries with other comorbidities in SCD. His goal is to identify prophylactic and therapeutic targets in preclinical settings with translational capabilities, and to provide new biomarkers for better prognostication and risk assessment for SCD complications.
Publications
For my complete bibliography,
Click Here
.
Selected Publications:
Ofori-Acquah SF, Hazra R, Orikogbo OO, Crosby D, Flage B, Ackah E, Lenhart D, Tan R, Vitturi D, Paintsil V, Owusu-Dabo E, Ghosh S. Hemopexin deficiency promotes acute kidney injury in sickle cell disease.
Blood
. 2020; 135(13): 144-148.
Ghosh S, Flage B, Weidert F, Ofori-Acquah SF. P-Selectin play a role in haem induced acute lung injury in sickle mice.
British J of Haematology
. 2019; 186(2): 329-333.
Ghosh S, Hazra R, Ihunnuh CA, Weidert F, Flage B, Ofori-Acquah SF. Augmented Nrf2 activation protects adult sickle mice from lethal acute chest syndrome.
British J of Haematology
. 2018; 182(2): 271-275.
Ghosh S, Ihunnah CA, Hazra R, Walker AL, Hansen JM, Archer DR, Owusu-Ansah AT, Ofori-Acquah SF. Nonhematopoietic Nrf2 dominantly impedes adult progression of sickle cell anemia in mice.
JCI Insight
. 2016; 1(4).
Ghosh S, Adisa OA, Chappa P, Tan F, Jackson KA, Archer DR, Ofori-Acquah SF. Extracellular hemin crisis triggers acute chest syndrome in sickle mice.
Journal of Clinical Investigation
. 2013; 123(11): 4809-4820.
Sponsored Research/Activities
Title:
Molecular and Cellular Pathogenesis of Kidney Disease in Sickle Cell Disorders
Role:
Principal Investigator
Funding Agency:
National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number:
R01 DK124426
Start Year:
2021
End Year:
2024
Title:
Molecular and Cellular Pathogenesis of Kidney Disease in Sickle Cell Disorders
Role:
Principal Investigator
Funding Agency:
National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number:
R01 DK124426
Start Year:
2021
End Year:
2024
Title:
Pathobiology of Kidney Injury in Sickle Cell Disease
Role:
Principal Investigator
Funding Agency:
Samuel and Emma Winters Foundation
Start Year:
2019
End Year:
2020
Title:
Hemostasis and Vascular Biology Research Institute
Role:
Principal Investigator
Funding Agency:
Hemophilia Center of Western PA
Grant Number:
RES
Start Year:
2018
End Year:
2022
My Lab
My Research
