Department of Medicine
Faculty Profiles by Division

Division of Hematology/Oncology

Faculty Profiles

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photo Nadine Hempel, PhD


Associate Professor of Medicine, Division of Hematology/Oncology

Faculty Member, Cancer Biology Program, UPMC Hillman Cancer Center


Phone: 412-641-4174

Office: Magee-Womens Research Institute A410
204 Craft Ave
Pittsburgh, PA 15213
Phone: 412-641-4174
Administrative Assistant:
Renee Mandell
Address: Magee Womens Research Institute
Pittsburgh, PA 15213
Phone: 412-641-7724
Fax: 412-641-2458
Administrative Assistant:
Nadine Ryan
Education and Training
BSc (Hons), University of Queensland, 1999
PhD, University of Queensland, 2004
Post-doctoral Fellow, Duke University Medical Center, 2007
Post-doctoral Fellow, Albany Medical College, 2011
Research Interest
Dr. Nadine Hempel's research interests center on understanding molecular mechanisms that regulate metastasis and tumor recurrence of ovarian cancer, with the ultimate goal of identifying novel targets for therapy of advanced-stage disease.

Her research group uses a variety of molecular, cellular, imaging and in vivo techniques to focus on two research areas in cancer biology: first, the role of mitochondrial antioxidants and reactive oxygen species during metastatic progression; and second, the regulation of mitochondrial dynamics and metabolism in ovarian cancer.
For my complete bibliography, Click Here.
Selected Publications:
Kim YS, Gupta Vallur P, Jones VM, Worley BL, Shimko S, Shin DH, Crawford LC, Chen CW, Aird KM, Abraham T, Shepherd TG, Warrick JI, Lee NY, Phaeton R, Mythreye K, Hempel N. Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells. Oncogene. 2020; 39(8): 1619-1633.
Pathak T, Gueguinou M, Walter V, Delierneux C, Johnson MT, Zhang X, Xin P, Yoast RE, Emrich SM, Yochum GS, Sekler I, Koltun WA, Gill DL, Hempel N, Trebak M. Dichotomous role of the human mitochondrial Na+/Ca2+/Li+ exchanger NCLX in colorectal cancer growth and metastasis. Elife. 2020; 9: e59686.
Worley BL, Kim YS, Mardini J, Zaman R, Leon KE, Vallur PG, Nduwumwami A, Warrick JI, Timmins PF, Kesterson JP, Phaëton R, Lee NY, Walter V, Endres L, Mythreye K, Aird KM, Hempel N. GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment. Redox Biology. 2019; 25: 101051.
Hempel N, Trebak M. Crosstalk between calcium and reactive oxygen species signaling in cancer. Cell Calcium. 2017; 63: 70-96.
Hemachandra LP, Shin DH, Dier U, Iuliano JN, Engelberth SA, Uusitalo LM, Murphy SK, Hempel N. Mitochondrial Superoxide Dismutase Has a Protumorigenic Role in Ovarian Clear Cell Carcinoma. Cancer Research. 2015; 75(22): 4973-84.
Notable Achievements
Member, NIH Tumor Progression Metastasis Study Section, 2020-2025
Dean’s Award for Excellence in Teaching, Penn State College of Medicine, 2021
Outstanding Collaborative Research Team Award, Penn State College of Medicine, 2020
Council Member & Chair of Professional Development, Society for Redox Biology and Medicine (SfRBM), 2015-2018
Scholar-in-Training Award, American Association for Cancer Research (AACR), 2010
Young Investigator Award, Society for Redox Biology and Medicine (SfRBM), 2008 & 2010
Member, Society for Redox Biology and Medicine (SfRBM), 2007-present
Member, American Association for Cancer Research (AACR), 2005-present