Department of Medicine
Faculty Profiles by Division

Division of Hematology/Oncology

Faculty Profiles
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photo Yufei Huang, PhD

Hematology/Oncology

Professor of Medicine

Leader, AI Research, UPMC Hillman Cancer Center

Member, Hillman Cancer Virology Program

Email: YUH119@pitt.edu

Phone: 412-623-2617
Contact
Office: Suite 1B, R126, UPMC Cancer Pavilion
5150 Centre Avenue
Pittsburgh, PA 15232
 
Phone: 412-623-2617
Fax:
E-mail: YUH119@pitt.edu
Administrative Assistant:
Samantha Coutch
Address: 5117 Centre Avenue
Pittsburgh, PA 15213
Email: coutchs@upmc.edu
Phone: 412-648-5012
Education and Training
Education
MS, Electrical Engineering, Stony Brook University, 1997
PhD, Electrical Engineering, Stony Brook University, 2001
Research Interest
Dr. Huang’s research focuses on
1. m6A methylation and its role in cancer.
His lab uses a combination of computation/AI and high throughput profiling technologies to 1) delineate regulation of m6A deposition; 2) determine the mechanisms by which m6A regulates gene expression and downstream functions; 3) m6A’s role in cancer and viral infection. His lab developed many computation tools and resources for analyzing m6A profiling data and predicting m6A functions including the exomePeak pipeline for detecting m6A and differential m6A sites from MeRIP-seq, m6A-express for predicting m6A-regulation of gene expression, FunDMDeep-m6A for prioritizing functional differential m6A sites, and the MeT-DB database.

2. AI for precision oncology.
Develop novel deep learning and AI models that can 1) perform cancer phenotype predictions and, at the same time, 2) identifying markers and generate explainable mechanisms. His lab has developed several genomics-based deep learning/AI tools for cancer prognosis and survival analysis, drug response prediction, and cancer gene dependence prediction.
Publications
For my complete bibliography, Click Here.
Selected Publications:
M Flores, Z Liu, TH Zhang, MM Hasib, YC Chiu, Z Ye, K Paniagua, S Jo, J. Zhang, S-J Gao, Y. Chen*, Y. Huang*. Deep learning tackles single-cell analysis A survey of deep learning for scRNA-seq analysis. arXiv preprint arXiv:2109.12404. 2021; *:corresponding_author.
Zhang, T., Zhang, S. W., Zhang, S. Y., Gao, S. J., Chen, Y.*, & Huang, Y.*. m6Aexpress: uncovering complex and condition-specific m6A regulation of gene expression. Nucleic Acids Research. 2021; gkab714.
Y-C Chiu, S. Zheng, L-J Wang, B. S. Iskra, M. K. Rao, P. J. Houghton, Y. Huang*, Y. Chen*. Predicting and characterizing a cancer dependency map of tumors with deep learning. Science Advances. 2021; 7 (34), eabh1275.
Mostavi, M., Chiu, Y.C., Chen, Y.* and Huang, Y.*. CancerSiamese: one-shot learning for predicting primary and metastatic tumor types unseen during model training. BMC bioinformatics. 2021; 22(1), pp.1-17.
Chiu YC, Chen HI, Gorthi A, Mostavi M, Zheng S, Huang Y*, Chen Y*. Deep learning of pharmacogenomics resources: moving towards precision oncology. Briefings in Bioinformatics. 2020; bbz144, https://doi.org/10.1093/bib/bbz144.
Gruffaz, M., Zhang, T., Marshall, V., Goncalves, P., Ramaswami, R., Labo, N., Whitby, D., Uldrick, T, T. S., Yarchoan, R., Huang, Y., & Gao, S.-J.*. Signatures of oral microbiome in HIV-infected individuals with oral Kaposi's sarcoma and cell-associated KSHV DNA. PLOS PATHOGENS. 2020; 16(1).
Chiu YC, Chen HH, Zhang T, Zhang S, Gorthi A, Wang LJ, Huang Y, Chen Y. Predicting drug response of tumors from integrated genomic profiles by deep neural networks. BMC Med Genomics. 2019; 31;12(Suppl 1):18.
Panneerdoss S, Eedunuri VE, Timilsina S, Rajamanickam S, Suryavathi V, Abdelfattah S, Onyeagucha BC,, Cui X, Mohammad TA, Huang THM, Huang Y*, Chen Y*, Rao MK*. Cross-talk among writers, readers, and erasers of m6A regulates cancer growth and progression. Science Advances. 2018; 4(10).
Tan, B., Liu, H., Zhang, S., da Silva, S. R., Zhang, L., Meng, J., Cui, X., Yuan, H., Sorel, O., Zhang, S., Huang*, Y., Gao*, S-J. Viral and Cellular N6-Methyladenosine (m6A) and N6, 2'-ODimethyladenosine (m6Am) Epitranscriptomes in KSHV Life Cycle. Nature Microbiology. 2018; 3(1): 108-120.
Liu H, Wang H, Wei Z, Zhang S, Hua G, Zhang S, Zhang L, Gao S-J, Meng* J, Chen* X, Huang Y*. Elucidating context-specific functions of N6-methyl-adenosine methyltranscriptome. Nucleic Acids Research. 2018; 4;46(D1): D281-D287.
Notable Achievements
NSF Career Award, 2005
Best Paper Award, IEEE Signal Processing Magazine, 2007
UTSA Presidential Achievement Award in Research, 2018
Distinguished Service Award, International Association of Intelligent Biology and Medicine, 2019

Division Websites

Cardiology

Endocrinology and Metabolism

Gastroenterology, Hepatology and Nutrition

General Internal Medicine

Geriatric Medicine
Hematology/Oncology

Infectious Diseases

Pulmonary, Allergy and Critical Care Medicine

Renal-Electrolyte

Rheumatology and Clinical Immunology

Contact

Department of Medicine
1218 Scaife Hall
3550 Terrace Street
Pittsburgh, PA 15261
Email:  chairoff@pitt.edu
Phone:  412-648-9636
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