Department of Medicine
Faculty Profiles by Division

Division of Hematology/Oncology

Faculty Profiles

[Return To Index page]
photo Jason J Luke, MD, FACP


Director of the Cancer Immunotherapeutics Center


Phone: 412-623-4511

Office: 5150 Centre Avenue
UPMC Cancer Pavilion, 5th floor, Room 563
Pittsburgh, PA 15232
Phone: 412-623-4511
Fax: 412-623-7948
Administrative Assistant:
Jana Parks
Address: 5150 Centre Ave.
UPMC Cancer Pavilion, 5th floor, 553b
Pittsburgh, PA 15232
Phone: 412-692-2600
Fax: 412-648-6579
Education and Training
MD, Rosalind Franklin University of Medicine and Science/Chicago Medical School, 2006
Internal Medicine Residency, Boston University Medical Center, 2009
Medical Oncology and Medicine Fellowships, Memorial Sloan-Kettering Cancer Center and Weill Cornell Medical Center, 2012
Research Interest
I am Associate Professor of Medicine at the University of Pittsburgh Medical Center and Director of the Cancer Immunotherapeutics Center at Hillman Cancer Center who focuses on translational therapeutic advances for malignant melanoma and early phase drug development for advanced cancers. I have particular expertise in the immunotherapy of cancer, having been a lead investigator for immunotherapies such as anti-PD1/L1, CTLA4, LAG3, TIM3, GITR, OX40, CD137, CD40, inhibitors of indolamine-dioxygenase, adenosine A2a receptor & arginase as well as agonists of STING & oncolytic virus. I maintain an on-going interest in the molecular biology of cancer and particularly in the intersection between oncogene targeted small molecules and immunotherapy. I have pursued large scale biobanking efforts surrounding cancer immunotherapy and am interested in identifying tumor-intrinsic mechanisms of immune exclusion from patient samples by employing multi-omic bioinformatic approaches. I have been successful in obtaining independent support for clinical investigation from private, public and industry sources.
Clinical Interest
Phase I clinical trials, immunotherapy of cancer, drug development for cancer, melanoma
For my complete bibliography, Click Here.
Notable Achievements
Merit Award, American Society of Clinical Oncology, 2011
Young Investigator Award, Conquer Cancer Foundation of ASCO, 2011
Tract Leader, Melanoma, Cancer Education Committee, ASCO, 2013
Denise and Michael Kellen - Melanoma Research Alliance Young Investigator, 2014
Paul Calabresi Career Development in Clinical Oncology Award, 2014
Young Investigator Award, Cancer Research Foundation, 2015
Humanitarian Award, Melanoma Research Foundation, 2018
40 Under 40, Crain’s Business Chicago, 2018
Member, ASCO Melanoma Science Committee, 2018
Cancer Clinical Investigator Team Leadership Award, NIH/NCI, 2018