Department of Medicine
Faculty Profiles by Division

Division of Hematology/Oncology

Faculty Profiles

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photo Tirthadipa Pradhan-Sundd, PhD

Hematology/Oncology

Assistant Professor of Medicine

Email: tip9@pitt.edu

Phone: 412-648-9987

Contact
Office: BST W1055
200 Lothrop Street
Pittsburgh, PA 15261
 
Phone: 412-648-9987
Fax:
E-mail: tip9@pitt.edu
Education and Training
Education
B.Sc and M.Sc, University of Calcutta, India
M.Phil, University of Sheffield, UK, 2011
PhD, Simon Fraser University,Canada, 2015
Training
Post Doctoral Fellow, University of Pittsburgh, 2018
Instructor, University of Pittsburgh, 2019
Research Interest
Our goal is to gain a better understanding of the mechanisms involved in the development and maintenance of the vascular processes in liver development and disease. Our disease models include sickle cell disease induced acute and chronic liver injury, iron homeostasis in the liver, models of vasculopathy (fibrosis/cirrhosis/portal hypertension), Factor VIII in chronic liver diseases and regulators of vascular pathology including inflammasomes and signaling pathways.
Educational Interest
Dr. Pradhan-Sundd is interested in mentoring undergraduate, graduate, postdoctoral fellows and clinical research fellows in Sickle cell disease related liver injury, Hemophilia associated liver diseases and Liver inflammation research.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Vats R, Kaminski T, Ju E-M, Brozska T, Tutuncuoglu E, Tejero J, Novelli E, Sundd P, Pradhan-Sundd T. P-selectin deficiency promotes liver senescence in sickle cell disease mice. Blood. Feb 22. 2021.
Vats R, Liu S, Zhu J, Mukhi D, Tutuncuoglu E, Cardenes N, Singh S, Brzoska T, Kosar K, Bamne M, Jonassaint J, Michael AA, Watkins SC, Hillery C, Ma X, Nejak-Bowen K, Rojas M, Gladwin MT, Kato GJ , Ramakrishnan R, Sundd P,Monga SP, Pradhan-Sundd T. Impaired bile secretion promotes hepatobiliary injury in Sickle Cell Disease. Hepatology. 2020.
Pradhan-Sundd T*, Gudapati S, Kaminski T, Ragni M. Exploring the complex role of procoagulant Factor VIII in chronic liver disease. Cell Mol Gastroenterol Hepatol. 2021; Review Article. *first and corresponding author. Cellular Molecular Gastroenterology Hepatology. 2021.
Vats R, Kaminski T W, Pradhan-Sundd T. Intravital imaging of hepatic blood biliary barrier in live mice. Manuscript accepted, in press. August, 2021. Current protocols in Cytometry. 2021.
Vats R, Brzoska T, Bennewitz MF, Jimenez MA, Pradhan-Sundd T, Tutuncuoglu E, Jonassaint J, Gutierrez, Watkins SC, Shiva S, Scott M, Morelli AE, Neal MD, Kato GJ, Gladwin MT, Sundd P. Platelet Extracellular Vesicles Drive Inflammasome-IL1ß-dependent Lung Injury in Sickle Cell Disease. Am J Respir Crit Care Med. 2019.
Nolfi-Donegan D, Pradhan-Sundd T, Pritchard KA Jr, Hillery CA. Redox Signaling in Sickle Cell Disease. Curr Opin Physiol. 2019; 9: 26-33.
Sponsored Research/Activities
Title: Molecular Mechanism of Sickle Cell Hepatic Crisis
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: K01 DK125617
Start Year: 2020
End Year: 2025
Title: Identifying molecular targets of Sickle cell disease induced chronic liver injury
Role: Principal Investigator
Funding Agency: American Gastroenterology Association Fnd
Start Year: 2020
End Year: 2021
Title: Molecular mechanism of Sickle Cell Hepatic Crisis
Role: Principal Investigator
Funding Agency: Community Liver Alliance
Start Year: 2018
End Year: 2019
Title: Digestive Diseases Training Program
Role: Fellow
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: T32 DK063922
Start Year: 2015
End Year: 2017
Notable Achievements
2020 AGA Elsevier Pilot Research Funding Award, 2020
HCS New Investigator Award, 2020
Dani and Eric Zander Junior Faculty Scholar Award, 2020
Community Liver Alliance Research Funding, 2018
Pittsburgh Intensive Training in Haematology Research (R25), 2019
Ralph D. Lillie Award, Histochemical Society, 2016
NIH-T32 Post-doctoral Fellowship, 2015-2017
Weyerhaeuser Molecular Biology PhD Scholarship, SFU, 2012
Presidents PhD Research Scholarship, SFU, 2014