Department of Medicine
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Division of Hematology/Oncology

Faculty Profiles

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photo Tirthadipa Pradhan-Sundd, PhD

Hematology/Oncology

Research Assistant Professor of Medicine

Faculty Member: Sickle Cell Center of excellence, U.Pitt and UPMC

Faculty Member: Pittsburgh Liver Research Centre

Faculty Member: McGowan Institute for Regenerative Medicine, University of Pittsburgh.

Email: tip9@pitt.edu

Phone: 412-648-9987

Contact
Office: BST E1226-2A
200 Lothrop Street
Pittsburgh, PA 15261
 
Phone: 412-648-9987
Fax:
E-mail: tip9@pitt.edu
Education and Training
Education
B.Sc and M.Sc, University of Calcutta, India
M.Phil, University of Sheffield, UK, 2011
PhD, Simon Fraser University,Canada, 2015
Training
Post Doctoral Fellow, University of Pittsburgh, 2018
Instructor, University of Pittsburgh, 2019
Research Interest
Liver fibrosis, inflammation and loss of blood biliary barrier are the hallmark of chronic liver injury. Several experimental models have been used to mimic the end-stage pathophysiology of chronic liver injury. However, the underlying differences in the molecular mechanism driving liver injury in different models remains largely unknown due to our inability to visualize the progression of liver injury in vivo in mice. We have introduced quantitative Liver Intravital Microscopy (qLIM) that enables real-time assessment of bile transport and blood-bile barrier (BBlB) integrity in the intact liver of live mice (Pradhan-Sundd et al., Hepatology, 2017, Gastroenterology, 2018). Using qLIM, we aim to understand the mechanisms of chronic live injury initiation, progression, and recovery processes in experimental and disease models.
One of our longstanding interest is to understand the molecular mechanism of Sickle cell hepatic crisis. Sickle cell disease (SCD) is an autosomal recessive genetic disorder that affects ~100,000 Americans and millions of people worldwide. Sickle cell anemia can affect any part of the body and one of the main organs to be affected is the hepatobiliary system. We have used a transgenic, humanized mouse model of SCD that exclusively expresses sickle human hemoglobin. Using qLIM, we identified sinusoidal ischemia, impairment of canalicular bile secretion, and intrahepatic accumulation of bile acids in SCD mice. Understanding the molecular events that initiate and promulgate SCD induced hepatobiliary injury has great potential to prevent hepatic insult and progressive liver damage in SCD.
Educational Interest
Dr. Pradhan-Sundd is interested in mentoring undergraduate, graduate, postdoctoral fellows and clinical research fellows in Sickle cell liver injury and Liver inflammation research.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Pradhan-Sundd T, Vats R, Russell J, Monga SP, Sundd P. Dysregulated tight junctional proteins and bile transporters enables chronic liver injury. Gastroenterology. 2018; S0016-5085(18): 34690-0.
Pradhan-Sundd T, Zhou L, Vats R, Molina L, Singh S, Watkins S, Sundd P, Monga SP. Dual beta-catenin and gamma-catenin loss disrupts hepatic tissue barrier to cause cholestatic liver disease. Hepatology. 2017.
Zhou L, Pradhan-Sundd T, Poddar M, Singh S, Kikuchi A, Stolz DB, Shou W, Li Z, Nejak-Bowen KN, Monga SP. Mice with Hepatic Loss of the Desmosomal Protein ?-Catenin Are Prone to Cholestatic Injury and Chemical Carcinogenesis. Am J Pathol. 2015; 185(12): 3274-89.
Tirthadipa Pradhan-Sundd, Satdarshan Pal Monga. Blood-Bile Barrier: Morphology, Regulation, and Pathophysiology. Gene Expr. 2019; 18;19(2): 69-87.
Nolfi-Donegan D, Pradhan-Sundd T, Pritchard KA Jr, Hillery CA. Redox Signaling in Sickle Cell Disease. Curr Opin Physiol. 2019; 9: 26-33.
Vats R, Brzoska T, Bennewitz MF, Jimenez MA, Pradhan-Sundd T, Tutuncuoglu E, Jonassaint J, Gutierrez, Watkins SC, Shiva S, Scott M, Morelli AE, Neal MD, Kato GJ, Gladwin MT, Sundd P. Platelet Extracellular Vesicles Drive Inflammasome-IL1ß-dependent Lung Injury in Sickle Cell Disease. Am J Respir Crit Care Med. 2019.
Sponsored Research/Activities
Title: Identifying molecular targets of Sickle cell disease induced chronic liver injury
Role: Principal Investigator
Funding Agency: American Gastroenterology Association Fnd
Start Year: 2020
End Year: 2021
Title: Molecular mechanism of Sickle Cell Hepatic Crisis
Role: Principal Investigator
Funding Agency: Community Liver Alliance
Start Year: 2018
End Year: 2019
Title: Digestive Diseases Training Program
Role: Fellow
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: T32 DK063922
Start Year: 2015
End Year: 2017
Notable Achievements
2020 AGA Elsevier Pilot Research Funding Award, 2020
Pittsburgh Intensive Training in Haematology Research (R25), 2019
Community Liver Alliance Research Funding, 2018
PLRC Pilot and Feasibity Grant Award, 2018
HCS trainee travel award, 2016,2017,2018,2019
Ralph D. Lillie Award, Histochemical Society, 2016
NIH-T32 Post-doctoral Fellowship, 2015-2017
Weyerhaeuser Molecular Biology PhD Scholarship, SFU, 2012
Presidents PhD Research Scholarship, SFU, 2014