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Division of Infectious Diseases

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photo Anna Joanna Jasinska, PhD

Infectious Diseases

Assistant Professor of Medicine

Email: AJJ59@pitt.edu
Contact
Office: 3550 Terrace Street
Scaife Hall S827, University of Pittsburgh
Pittsburgh, PA 15213
 
E-mail: AJJ59@pitt.edu
Research Interest
My research focuses on functional genomics and systems biology studies of common chronic illnesses, affecting brain, neurobehavior, and metabolism, diseases caused by stress or infections with viral pathogens (SIV/HIV). Many of chronic conditions manifest in chronic inflammation and accelerated aging. I am using a combination of genomic, transcriptomic, and epigenetic approaches to unravel mechanisms of such aging- and inflammation-related phenotypes and identify targets for therapy. I am also interested in natural protective mechanisms that natural hosts have developed during a long-term coevolution with the pathogens.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Jasinska AJ, Apetrei C, Pandrea I. Walk on the Wild Side: SIV infection in African nonhuman primate hosts, from the field to the laboratory. Frontiers in Immunology. 2023; 13: 1060985.
Horvath S, Haghani A, Zoller JA, Lu AT, Ernst J, Pellegrini M, Jasinska AJ, Mattison JA, Salmon AB, Raj K, Horvath M, Paul KC, Ritz BR, Robeck TR, Spriggs M, Ehmke EE, Jenkins S, Li C, Nathanielsz PW. Pan-primate studies of age and sex. Geroscience. 2023; Jul 26.
Jasinska AJ, Pandrea I, Apetrei C. CCR5 as a Coreceptor for Human Immunodeficiency Virus and Simian Immunodeficiency Viruses: A Prototypic Love-Hate Affair. Frontiers in Immunology. 2022; 13: 835994.
Jasinska AJ, Haghani A, Zoller JA, Li CZ, Arneson A, Ernst J, Kavanagh K, Jorgensen MJ, Mattison JA, Wojta K, Choi OW, DeYoung J, Li X, Rao AW, Coppola G, Freimer NB, Woods RP, Horvath S. Epigenetic clock and methylation studies in vervet monkeys. GeroScience. 2022; 44: 699.
Horvath S, Zoller JA, Haghani A, Lu AT, Raj K, Jasinska AJ, Mattison JA, Salmon AB. DNA methylation age analysis of rapamycin in common marmosets. GeroScience. 2021; 43: 2413.
Horvath S, Zoller JA, Haghani A, Jasinska AJ, Raj K, Breeze CE, Ernst J, Vaughan KL, Mattison JA. Epigenetic clock and methylation studies in the rhesus macaque. GeroScience. 2021; 43: 2441.
Jasinska AJ, Pandrea I, He T, Benjamin C, Newton M, Lee JC, Freimer NB, Jentsch JD, Jentsch JD. Immunosuppressive effect and global dysregulation of blood transcriptome in response to psychosocial stress in vervet monkeys (Chlorocebus sabaeus). Scientific Reports. 2020; 10(1): 459.
Jasinska AJ, Dong TS, Lagishetty V, Katzka W, Jacobs JP, Schmitt C, Danzy Cramer J, Ma D, Coetzer WG, Grobler JP, Turner TR, Freimer N. Shifts in microbial diversity, composition, and functionality in the gut and genital microbiome during a natural SIV infection in vervet monkeys. Microbiome. 2020; 8: 154.
Jasinska AJ. Resources for functional genomic studies of health and development in nonhuman primates. Yearbook Am J Phys Anthropol. 2020; 171 Suppl 70: 174.
Schmitt CA, Bergey CM, Jasinska AJ, Ramensky V, Burt F, Svardal H, Jorgensen MJ, Freimer NB, Grobler P, Turner TR. ACE2 and TMPRSS2 variation in savanna monkeys (Chlorocebus spp.): Potential risk for zoonotic/anthroponotic transmission of SARS-CoV-2 and a potential model for functional studies. PLoS One. 2020; 15(6): e0235106.

Division Websites

Cardiology

Endocrinology and Metabolism

Gastroenterology, Hepatology and Nutrition

General Internal Medicine

Geriatric Medicine
Hematology/Oncology

Infectious Diseases

Pulmonary, Allergy and Critical Care Medicine

Renal-Electrolyte

Rheumatology and Clinical Immunology

Contact

Department of Medicine
1218 Scaife Hall
3550 Terrace Street
Pittsburgh, PA 15261
Email:  chairoff@pitt.edu
Phone:  412-648-9636
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