Office:	Scaife Hall, Suite 818
	3550 Terrace Street
	Pittsburgh, PA 15261
Phone:	412-624-8512
Fax:	412-383-7982
E-mail:	jwm1@pitt.edu

Education
	BA, Dartmouth College, Hanover, NH, 1975
	MD, Dartmouth Medical School, Hanover, NH, 1978

Training
	Internship/Residency Training, Yale-New Haven Hospital, New Haven, CT, 1982
	Infectious Diseases Fellowship Training, Yale University School of Medicine, New Haven, CT, 1985

Dr. Mellors led several studies with samples from the Multicenter AIDS Cohort Study (MACS) that established the critical relationship between plasma viremia (HIV-1 RNA) and HIV disease progression to AIDS and death in both acute and chronic HIV-1 infection. This work led to the universal use of plasma HIV-1 RNA and CD4+T-cell counts to estimate prognosis in HIV-1 infection and the optimal time to initiate antiretroviral therapy (ART). Dr. Mellors contributed to the development and testing of the first antiretroviral combinations that produced sustained suppression of viremia and recovery of CD4+T-cells that launched the current era of highly-effective ART. Presently, Dr. Mellors' laboratory focuses on resistance to antiretroviral drugs used for treatment and HIV prevention and on mechanisms of HIV persistence and strategies to deplete the reservoirs that are the barrier to curing HIV infection. His work on HIV reservoirs showed that low-level viremia persists in most individuals on long-term suppressive ART, and that the level of residual viremia is predicted by the level of viremia before ART. Current work focuses on identifying agents to reverse HIV latency and to eliminate HIV infected cells. The impact of innovative therapies on HIV reservoirs is being studied in Phase I/II trials of histone deacetylase inhibitors, monoclonal antibodies to immune checkpoint ligands, monoclonal antibodies to HIV envelope glycoproteins, and TLR agonists.

Dr. Mellors is the Chief of the Infectious Diseases Division, a Distinguished Professor of Medicine, the Endowed Chair for Global Elimination of HIV and AIDS at University of Pittsburgh School of Medicine, and, Executive Director of the HIV/AIDS Program with the University of Pittsburgh Medical Center (UPMC). He has served as Chief of the Division of Infectious Diseases in the Department of Medicine for more than 20 years. Under his leadership, the Division has grown to 68 faculty and 198 staff, with $3 million in annual clinical revenue. Dr. Mellors directs the primary care and clinical research activities in HIV/AIDS at UPMC Health System, providing care to over 1,700 HIV-infected individuals. His clinical interests are directed towards optimizing antiretroviral therapy of HIV infection, especially among individuals with antiretroviral drug resistance.

Dr. Mellors is a tenured Professor of Medicine, Pathology, and Infectious Diseases and Microbiology, who has as a strong reputation as a knowledgeable and enthusiastic mentor and teacher at the University of Pittsburgh. He has lectured on “HIV-AIDS” in the Medical Microbiology course, “HIV-1 Antiviral Strategies” in the Retrovirology course of the Molecular Virology and Microbiology program and “HIV Cure” in the Prevention, Treatment, and Control of Global Infectious Diseases course within the Department of Infectious Diseases and Microbiology curriculum. Dr. Mellors has a long history of mentorship of fellows, residents and medical students. He has mentored six post-doctoral fellows, eleven pre-doctoral candidates, and serves on numerous dissertation committees. Dr. Mellors offers trainees balanced guidance in the areas of research, authorship, grant writing, manuscript review and oral presentation based upon his extensive professional experience. Currently, one PhD student, a recipient of the Pitt AIDS Research Training (PART) Program award for pre-doctoral trainees, one Medical student, a recipient of two years of funding via the Medical Research Fellows Program awarded by the Howard Hughes Medical Institute (HHMI), and one post-doctoral associate, are benefiting from Dr. Mellors primary mentorship.

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Selected Publications: