Department of Medicine
Faculty Profiles by Division

Division of Infectious Diseases

Faculty Profiles

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photo David A. Nace, MD, MPH


Clinical Chief of Geriatric Medicine

Associate Professor of Medicine

Director of Long Term Care & Flu Programs / University of Pittsburgh

Institute on Aging, Medical Director


Phone: 412-692-2360

Office: 3471 Fifth Avenue
Kaufmann Building, Suite 500
Pittsburgh, PA 15213
Phone: 412-692-2360
Fax: 412-692-2370
Administrative Assistant:
Eileen Taylor
Address: 3471 Fifth Ave, Suite 500
Kaufmann Medical Bldg
Pittsburgh, PA 15213
Phone: 412-692-2385
Fax: 412-692-2370
Education and Training
•Medicine, Temple University, Philadelphia, PA, 1990
•MPH, University of Pittsburgh, 1995
•Internal Medicine Internship, Universtiy of Pittsburgh Medical Center, 1991
•Internal Medicine Residency, University of Pittsburgh Medical Center, 1993
•Geriatrics Fellowship, University of Pittsburgh Medical Center, 1995
Research Interest
Dr. Nace is an Associate Professor whose primary research interest focuses on infectious disease in older adults, particularly COVID-19, antimicrobial stewardship, and vaccine preventable diseases. Present work includes evaluating the impact of ringed approach to management of COVID-19 outbreaks in long-term care (LTC) facilities, and characterizing antibody response to COVID-19 vaccination in older LTC residents. Through a series of AHRQ funded studies, Dr. Nace lead a team developing the first evidence supported, consensus based treatment guidelines for the diagnosis and treatment of uncomplicated cystitis in frail LTC residents. In a national dissemination and implementation study funded by AHRQ, use of the guidelines resulted in a 27% reduction in unnecessary antimicrobial use for UTI, and was associated with a two-thirds lower risk of Clostridium difficile infection. Continued work on this project focuses on improving training and uptake of the guidelines. He is also working with colleagues to improve construction and utilization of antibiograms in LTC facilities. Currently, Dr. Nace serves as the physician lead on a CDC grant that seeks to improve staff and resident immunizations across all LTC populations and settings. He also focuses work on the association between frailty, sarcopenia and vaccine response.

Additional areas of collaborative research involvement center around reducing unnecessary admissions and readmissions among nursing home residents (CMMI funded demonstration project), inter-professional education (CMMI funded demonstration project and Macy Foundation), osteoporosis (NIH/NIA funded research), adverse drug events (AHRQ), and dementia care (Donaghue Foundation).
Clinical Interest
As Clinical Chief of Geriatric Medicine, Dr. Nace leads the Division’s clinical efforts which span hospital-based care, outpatient care, and long-term care (LTC). He is co-leading the implementation of the UPMC Center for Cognitive Health which takes a population health approach to those persons experiencing dementia as well as the cognitive impact of long-haul COVID-19. His long-standing work in LTC outbreak detection and response successfully prepared UPMC Senior Communities for the COVID-19 pandemic. This work served as the model for the LTC-based Regional Response Health Collaborative program that Dr. Nace helped pioneer in collaboration with the Commonwealth of Pennsylvania and other academic health centers. The RRHCP program provided onsite infection control assessments and critical COVID-19 outbreak assistance to the Commonwealth’s LTC facilities.
For my complete bibliography, Click Here.
Selected Publications:
Weber, D., Al-Tawfiq, J., Babcock, H., Bryant, K., Drees, M., Elshaboury, R., Essick, K., Mohamad, F., Henderson, D., Javaid, W., Juffras, D., Jump, R.L.P., Lee, F., Malani, A.N., Mathew, T., Murthy, A.R., Nace, D., O'Shea, T., Pettigrew, E., Pettis, A.M., Schaffzin, J., Shenoy, E.S., Vaishampayan, J., Wiley, Z., Wright, S.B., Yokoe, D., Young, H. Multisociety statement on coronavirus disease 2019 (COVID-19) vaccination as a condition of employment for healthcare personnel. Infection Control & Hospital Epidemiology. 2021.
Bariola, J.R., McCreary, E.K., Wadas, R.J., Kip, K.E., Marroquin, O.C., Minnier, T., Koscumb, S., Collins, K., Schmidhofer, M., Shovel, J.A., Wisniewski, M.K., Sullivan, C., Yealy, D.M., Nace, D.A., Huang, D.T., Haidar, G., Khadem, T., Linstrum, K., Seymour, C.W., Montgomery, S.K., Angus, C.D., Snyder, G.M. Impact of Bamlanivimab Monoclonal Antibody Treatment on Hospitalization and Mortality Among Nonhospitalized Adults With Severe Acute Respiratory Syndrome Coronavirus 2 Infection. Open Forum Infectious Diseases. 2021; 8(7).
Nace, D.A., Kip, K.E., Mellors, J.W., Peck Palmer, O.M., Shurin, M.R., Mulvey, K., Crancall, M., Sobolewski, M.D., Enick, P.N., McCormick, K.D., Jacobs, J.L., Kane, A.L., Lukanski, A., Kip, P.L., Wells, A. Antibody Responses After mRNA-Based COVID-19 Vaccination in Residential Older Adults: Implications for Reopening. Journal of the American Medical Directors Association. 2021; 22(8): 1593-1598.
Nace, D.A., Hanlon, J.T., Crnich, C.J., Drinka, P.J., Schweon, S.J., Anderson, G., Perera, S. A Multifaceted Antimicrobial Stewardship Program for the Treatment of Uncomplicated Cystitis in Nursing Home Residents. JAMA Internal Medicine. 2020; 180(7): 944-951.
Nace, D.A., Perera, S.K., Hanlon, J.T., Saracco, S., Anderson, G., Schweon, S.J., Klein-Fedyshin, M., Wessel, C.B., Mulligan, M., Drinka, P.J., Crnich, C.J. The Improving Outcomes of UTI Management in Long-Term Care Project (IOU) Consensus Guidelines for the Diagnosis of Uncomplicated Cystitis in Nursing Home Residents. Journal of the American Medical Directors Association. 2018; 19(9): 765-769.
Hanlon, J.T., Perera, S., Drinka, P.J., Crnich, C.J., Schweon, S.J., Klei-Fedyshin, M., Wessel, C.B., Saracco, S., Anderson, G., Mulligan, M., Nace, D.A. The IOU Consensus Recommendations for Empirical Therapy of Cystitis in Nursing Home Residents. Journal of the American Geriatrics Society. 2019; 67(3): 539-545.
Nace, D.A., Drinka, P.A., Crnich, C.J. Clinical uncertainties in the approach to long term care residents with possible urinary tract infection. Journal of the American Medical Directors Association. 2014; 15(2): 133-9.
Nace, D.A., Lin, C.J., Ross, T.M., Saracco, S., Churilla, R.M., Zimmerman, R.K. Randomized, controlled trial of high-dose influenza vaccine among frail residents of long-term care facilities. The Journal of Infectious Diseases. 2015; 211(12): 1915-24.
Nace, D.A., Archbald-Pannon, L.R., Ashraf, M.S., Drinka, P.J., Frfentzel, E., Gaur, S., Mahajan, D., Mehr, D.R., Mercer, W.C., Sloane, P.D., Jump, R.L.P. Pneumococcal Vaccination Guidance for Post-Acute and Long-Term Care Settings: Recommendations From AMDA's Infection Advisory Committee. Journal of the American Medical Directors Association. 2017; 18(2): 99-104.
Nace, D.A., Handler, S.M., Hoffman, E.L., Perera, S. Impact of the raising immunizations safely and effectively (RISE) program on healthcare worker influenza immunization rates in long term care settings. Journal of the American Medical Directors Association. 2012; 13(9): 806-10.
Sponsored Research/Activities
Title: Modified Medication Appropriateness Index for Uncomplicated Cystitis
Role: Principal Investigator
Funding Agency: Commonwealth of Pennsylvania
Start Year: 2019
End Year: 2019
Role: Co-Investigator
Funding Agency: National Institute of Aging
Grant Number: P30 AG024827
Start Year: 2020
End Year: 2025
Title: Innovative Approach to Geriatric Osteoporosis
Role: Co-Investigator
Funding Agency: National Institute of Aging
Grant Number: R01 AG066825
Start Year: 2020
End Year: 2025
Title: Outpatient VE for Seasonal Flue, Pandemic Flu and RSV in a Large, Diverse Network
Role: Co-Investigator
Funding Agency: Center for Disease Control
Grant Number: U01 IP001035
Start Year: 2017
End Year: 2019
Title: Sustaining Skeletal Health in Frail Elderly
Role: Co-Investigator
Funding Agency: National Institute of Aging
Grant Number: R01 AG052123
Start Year: 2016
End Year: 2021
Title: Maintenance of Skeletal Integrity in Frail Elders - Phase 2
Role: Co-Investigator
Funding Agency: National Institute of Aging
Grant Number: R01 AG050302
Start Year: 2015
End Year: 2020
Title: Pittsburgh Older Americans Independence Center RC1
Role: Core Leader
Funding Agency: National Institute of Aging
Grant Number: P30 AG024827
Start Year: 2015
End Year: 2020
Notable Achievements
•Immediate Past President, AMDA - The Society for Post-Acute and Long-Term Care Medicine, 2021-2022
•Grand Champion Award, UPMC Senior Commmunities Senior Champion, 2021
•Commitment and Excellence in Service Award, UPMC Aces, 2011, 2021
•President, AMDA-The Society for Post-Acute and Long-Term Care Medicine, 2020-2021
•Member, National Coronavirus Commission for Safety and Quality in Nursing Homes, 2020
•Member, Pneumococcal Vaccine Work Group, Advisory Committee on Immunization Practices (ACIP), 2020-present
•Member, PA Department of Health Advisory Health Board, 2019-present
•AMDA/ABIM Choosing Wisely Campaign Champion, 2019
•Member, PA Department of Health LTC Regulatory Work Group, 2017-present
•Member, PA Department of Aging LTC Council, 2016-present