Department of Medicine
Faculty Profiles by Division

Division of Infectious Diseases

Faculty Profiles

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photo Giraldina J Trevejo-Nunez, MD

Infectious Diseases


Phone: 412-383-5943

Office: 3500 Terrace Street
BST South 7th Floor, 717A
Pittsburgh, PA 15260
Phone: 412-383-5943
Education and Training
MD, Universidad Nacional Mayor de San Marcos, 2000
Master of Science, Rockefeller University, 2013
Internship in Internal Medicine, University of Texas Medical Branch, 2003
Residency in Internal Medicine, University of Texas Medical Branch, 2005
Fellowship in Infectious Diseases, New York University, 2007
Research Interest
Dr. Trevejo-Nunez is interested in the role of IL-22/ IL-22Ra2 during pneumococcal pneumonia. In United States, pneumococcal pneumonia (lung infection caused by Streptococcus pneumoniae) accounts for significant percentage of morbidity and mortality. The most vulnerable population are children younger than 2 years old and individuals older than 65. Interleukin-22 (IL-22) signaling in the liver is important for control of pneumococcal pneumonia and treatment with this cytokine improves bacterial burden in animal models. Dr. Trevejo-Nunez overall hypothesis is that enhancement of IL-22 signaling, through therapeutic administration of IL-22 or absence of decoy receptor IL-22Ra2, favors bacterial clearance and host survival by sustaining the levels of STAT3 activation in lung epithelium and liver during in pneumococcal pneumonia. Dr. Trevejo-Nunez is also interested in the metabolic pathways used by alveolar macrophages in response to bacterial infections
Clinical Interest
Host immune response against bacterial pneumonia.
Genetic predisposition to infections.
Educational Interest
Dr. Trevejo-Nunez is involved in the Medical Microbiology course for the first-year medical students.
Sponsored Research/Activities
Title: IL-22bd regulates oxidative phosphorylation during pneumococcal lung infection
Role: Principal Investigator
Funding Agency: Samuel and Emma Winters Foundation
Start Year: 2018
End Year: 2019
Title: Role of IL-22/IL-22RA2 During Pneumococcal Pneumonia
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: K01 HL135476
Start Year: 2017
End Year: 2022