Department of Medicine
Faculty Profiles by Division

Division of Pulmonary, Allergy and Critical Care Medicine

Faculty Profiles

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photo Seyed Mehdi Nouraie, MD, PhD

Pulmonary, Allergy and Critical Care Medicine

Associate Professor of Medicine

Email: nouraies@upmc.edu

Phone: 412-648-6494

Contact
Office: UPMC Montefiore Hospital, NW628
3459 Fifth Avenue
Pittsburgh, PA 15213
 
Phone: 412-648-6494
Fax: 412-648-6495
E-mail: nouraies@upmc.edu
Administrative Assistant:
Stacie Truszkowski
Email: truszkowskisl@upmc.edu
Phone: 412-624-7225
Fax: 412-624-1670
Education and Training
Education
MD, Tehran University of Medical Sciences, 1996
PhD, Epidemiology, Tehran University of Medical Sciences, 2000
Research Interest
Dr. Nouraie's outstanding skills as a biostatistician and epidemiologist helped facilitate the development of several key studies in the area of sickle cell disease and chronic pulmonary including projects on transition to adult care, predictors of pulmonary hypertension in sickle cell disease, and application of big administrative data in sickle cell disease and HIV outcome studies. His research on the design and analysis of clinical studies in the area of GI benign and malignant disease, sickle cell, and cardiopulmonary disorders has resulted in over 200 peer reviewed publications. Currently he is interested in assessing the cardiopulmonary complication of sickle cell disease and HIV infection as well as biomarker validation in cardiopulmonary diseases.
Educational Interest
Dr. Nouraie has been involved in teaching clinical epidemiology and study design. His education interest also includes application of biostatistical methods in causal inference and biomarker validation.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Nouraie M, Zhang X, Srisuwananukorn A, Machado RF, Gordeuk VR, Gladwin MT, et al. Potential Contribution of Pulmonary Thromboembolic Disease in Pulmonary Hypertension in Sickle Cell Disease. Ann Am Thorac Soc. 2020; Mar 18.
Nouraie M, Darbari DS, Rana S, Minniti CP, Castro OL, Luchtman Jones L, et al. Tricuspid Regurgitation Velocity and Other Biomarkers of Mortality in Children, Adolescents and Young Adults with Sickle Cell Disease in the United States: the PUSH Study. Am J Hematol. 2020; April 3.
Nouraie M, Little JA, Hildesheim M, Gibbs JSR, Morris CR, Machado RF, et al. Validation of a composite vascular high-risk profile for adult patients with sickle cell disease. Am J Hematol. 2019; Dec;94(12): E312-E4.
Rose JJ, Nouraie M, Gauthier MC, Pizon AF, Saul MI, Donahoe MP, et al. Clinical Outcomes and Mortality Impact of Hyperbaric Oxygen Therapy in Patients With Carbon Monoxide Poisoning. Crit Care Med. 2018; Jul;46(7): e649-e55.
Fitzpatrick ME, Nouraie M, Gingo MR, Camp D, Kessinger CJ, Sincebaugh JB, et al. Novel relationships of markers of monocyte activation and endothelial dysfunction with pulmonary dysfunction in HIV-infected persons. AIDS. 2016; Jun 1;30(9): 1327-39.
Castro, O, Nouraie, M, Oneal, P. Hydroxycarbamide treatment in sickle cell disease: Estimates of possible leukaemia risk and of hospitalization survival benefit. Br J Haematol. 2014; 167(5): 687-91.
Nouraie, M, Lee, JS, Zhang, Y, Kanias, T, Zhao, X, Xiong, Z, Oriss, TB, Zeng, Q, Kato, GJ, Gibbs, JS, Hildesheim, MD, Sachdev, V, Barst, RJ, Machado, RF, Hassell, KL, Little, JA, Schraufnagel, DE, Krishnamurti, L, Novelli, E, Girgis, RE. The relationship between the severity of hemolysis, clinical manifestations and risk of death in 415 patients with sickle cell anemia in the US and Europe. Haematologica. 2013; 98(3): 464-72.
Nouraie, M, Nekhai, S, Gordeuk, VR. Sickle cell disease is associated with decreased HIV but higher HBV and HCV comorbidities in U.S. hospital discharge records: A cross-sectional study. Sex Transm Infect. 2012; 88(7): 528-33.
Sachdev, V, Kato, GJ, Gibbs, JS, Barst, RJ, Machado, RF, Nouraie, M, Hassell, KL, Little, JA, Schraufnagel, DE, Krishnamurti, L, Novelli, EM, Girgis, RE, Morris, CR, Rosenzweig, EB, Badesch, DB, Lanzkron, S, Castro, OL, Taylor, JGt, Hannoush, H, Goldsmith, JC. Echocardiographic markers of elevated pulmonary pressure and left ventricular diastolic dysfunction are associated with exercise intolerance in adults and adolescents with homozygous sickle cell anemia in the United States and United Kingdom. Circulation. 2011; 124(13): 1452-60.
Nouraie, M, Reading, NS, Campbell, A, Minniti, CP, Rana, SR, Luchtman-Jones, L, Kato, GJ, Gladwin, MT, Castro, OL, Prchal, JT, Gordeuk, VR. Association of G6PD with lower haemoglobin concentration but not increased haemolysis in patients with sickle cell anaemia. Br J Haematol. 2010; 150(2): 218-25.
Sponsored Research/Activities
Title: Proj 3 - Immunosuppression in Acute Lung Injury
Role: Co-Investigator
Funding Agency: Ohio State University/ National Heart, Lung, & Blood Institute
Grant Number: P01 HL114453
Start Year: 2019
End Year: 2024
Title: Core B-Immunosuppression in acute lung injury
Role: Co-Investigator
Funding Agency: Ohio State University/ National Heart, Lung, & Blood Institute
Grant Number: P01 HL114453
Start Year: 2019
End Year: 2024
Title: Progressive Degenerative Role of Nox and Thrombospndin-1 in the Aging
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL142248
Start Year: 2019
End Year: 2023
Title: A Phase II Trial of Metformin for Pulmonary Hypertension in Heart Failure with Preserved Ejection Fraction
Role: Co-Investigator
Funding Agency: National Institute of Aging
Grant Number: R01 AG058659
Start Year: 2018
End Year: 2023
Title: Novel Mechanisms and Biomarkers of COPD/Emphysema
Role: Co-Investigator
Funding Agency: Glaxo, Inc.
Start Year: 2018
End Year: 2020
Title: Type-2 or Not Type-2: That is the (Therapeutic) Question
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: UG1 HL139098
Start Year: 2017
End Year: 2023
Title: Mechanisms of Host Protection Against Pathogen-Secreted Proteases in Acute Lung Injury
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL136143
Start Year: 2017
End Year: 2022
Title: Dysbiosis Impact on Lung Disease in HIV (DimpL) Study
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL138630
Start Year: 2017
End Year: 2021
Title: Lung Transplant Consortium
Role: Co-Investigator
Funding Agency: Cystic Fibrosis Foundation Therapeutics, Inc.
Grant Number: RES
Start Year: 2017
End Year: 2019
Title: University of Pittsburgh Multicenter AIDS Cohort Study (MACS)
Role: Co-Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: U01 AI035043
Start Year: 2016
End Year: 2018
Title: Leading Emerging and Diverse Scientists to Success (LEADS)
Role: Co-Investigator
Funding Agency: National Institute of General Medical Science
Grant Number: R25 GM116740
Start Year: 2015
End Year: 2020
Title: Adiposity and Airway Inflammation in HIV-Associated Airway Disease
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R56 HL128134
Start Year: 2015
End Year: 2016
Title: Cardiolipin as a Novel Mediator of Acute Lung Injury - Project 1
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: P01 HL114453
Start Year: 2014
End Year: 2018
Title: Longitudinal Evaluation of HIV-Associated Lung Disease Phenotypes
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL125049
Start Year: 2014
End Year: 2018
Title: Translational Evaluation of Aging, Inflammation, and HIV in Lung Dysfunction
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL120398
Start Year: 2013
End Year: 2018
Title: Hemostasis and Vascular Biology Research Institute - HCWP-VMI
Role: Co-Investigator
Funding Agency: Hemophilia Center of Western PA
Grant Number: RES
Start Year: 2008
End Year: 2018
Title: Impact of Poor Sleep on Inflammation and the Adenosine Signaling Pathway in HIV Infection
Role: Co-Leader
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL142118
Start Year: 2018
End Year: 2022
Title: Encore Retrospective Review on Sleep Disorder Breathing Users
Role: Statistician
Funding Agency: Respironics
Grant Number: RES
Start Year: 2018
End Year: 2020
Title: Cyb5R3 and cGMP Signaling
Role: Statistician
Funding Agency: Bayer Corporation
Grant Number: RES
Start Year: 2017
End Year: 2019
Title: University of Pittsburgh Multicenter AIDS Cohort Study (MACS)
Role: Statistician
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: U01 AI035043
Start Year: 2016
End Year: 2017
Title: Use of SGC Activators to Bypass NO Scavenging in SCD
Role: Statistician
Funding Agency: Bayer Corporation
Grant Number: RES
Start Year: 2014
End Year: 2017