Department of Medicine
Faculty Profiles by Division

Division of Pulmonary, Allergy and Critical Care Medicine

Faculty Profiles
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photo Jason J Rose, MD, MBA

Pulmonary, Allergy and Critical Care Medicine

Associate Professor of Medicine

Assistant Professor of Biomedical Engineering

Director of Innovation and Entrepreneurship

Email: rosejj@upmc.edu

Phone: 412-692-2134
Contact
Office: University of Pittsburgh Medical Center, NW 628
3459 Fifth Avenue
Pittsburgh, PA 15213
 
Phone: 412-692-2134
Fax: 412-692-2260
E-mail: rosejj@upmc.edu
Administrative Assistant:
Cindy Hatfield
Email: hatfieldca2@upmc.edu
Phone: 412-647-2461
Fax: 412-692-2260
Education and Training
Education
MBA, Carnegie Mellon University, 2017
MD, Wayne State University School of Medicine, 2010
BSE, Biomedical Engineering, University of Michigan, 2006
Training
Residency, Internal Medicine, Duke University Medical Center, 2013
Fellowship, Pulmonary & Critical Care Medicine, University of Pittsburgh Medical Center, 2016
Postdoctoral Fellowship, University of Pittsburgh, 2017
Research Interest
Dr. Rose's research interests focus on discovering and developing new human therapeutics. His group is working to identify and develop a novel carbon monoxide poisoning antidote. They are also characterizing the mechanisms of severe CO poisoning from a molecular basis and in novel animal models. Dr. Rose's research focuses on studying the mitochondrial effects of carbon monoxide and our ability to reverse the toxicity of carbon monoxide in vitro. He is interested in the drug development process, including nonclinical toxicology, pharmacodynamic and pharmacokinetic assessment, drug manufacturing and clinical study design.
Dr Rose also focuses on academic commercialization and innovation. Together with Drs Mark Gladwin and Jesus Tejero, he co-founded Globin Solutions Inc. (https://www.globinsolutions.com). He is co-inventor on five patents and patent applications.
Clinical Interest
Dr. Rose's clinical interests are in the management and care of critically ill patients. He rounds at UPMC Presbyterian, UPMC Montefiore, UPMC East, UPMC McKeesport and the Pittsburgh VA Medical Center. He has a particular interest in critical illness toxicology and inhalational lung disorders.
Educational Interest
Dr. Rose enjoys teaching and training medical students, residents and fellows in their clinical rotations in the Medical Intensive Care Unit.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Rose JJ, Bocian KA, Xu Q, Wang L, DeMartino AW, Chen X, Corey CG, Guimaraes DA, Azarov I, Huang XN, Tong Q, Guo L, Nouraie M, McTiernan CF, O'Donnell CP, Tejero J, Shiva S, Gladwin MT. A neuroglobin-based high-affinity ligand trap reverses carbon monoxide-induced mitochondrial poisoning. J Biol Chem. 2020; May 8;295(19): 6357-6371.
Zou RH, Tiberio PJ, Triantafyllou GA, Lamberty PE, Lynch MJ, Kreit JW, McVerry BJ, Gladwin MT, Morris A, Chiarchiaro J, Fitzpatrick ME, Rose JJ. Clinical Characterization of E-Cigarette, or Vaping, Product Use-associated Lung Injury in 36 Patients in Pittsburgh, Pennsylvania. Am J Respir Crit Care Med. 2020; May 15;201(10): 1303-1306.
Rose, J.J., Nouraie, M., Gauthier, M.C., Pizon, A.F., Saul, M.I., Donahoe, M.P., Gladwin, M.T. Clinical Outcomes and Mortality Impact of Hyperbaric Oxygen Therapy in Patients With Carbon Monoxide Poisoning. Crit Care Med. 2018; 2018 Apr 6 [Epub ahead of print].
Azarov I, Wang L, Rose JJ, Xu Q, Huang XN, Belanger A, Wang Y, Guo L, Liu C, Ucer KB, McTiernan CF, O'Donnell CP, Shiva S, Tejero J, Kim-Shapiro DB, Gladwin MT. Five-coordinate H64Q neuroglobin as a ligand-trap antidote for carbon monoxide poisoning. Sci Transl Med. 2016; Dec 7;8(368): 368ra173.
Rose JJ, Wang L, Xu Q, McTiernan CF, Shiva S, Tejero J, Gladwin MT. Carbon Monoxide Poisoning: Pathogenesis, Management, and Future Directions of Therapy. Am J Respir Crit Care Med. 2017; Mar 1; 195(5): 596-606.
Rose JJ, Xu Q, Wang L, Gladwin MT. Shining a Light on Carbon Monoxide Poisoning. Am J Respir Crit Care Med. 2015; Nov 15;192(10): 1145-7.
Rose JJ, Newby LK, Broderick S, Chiswell K, Van de Werf F, Armstrong PW, Mahaffey KW, Harrinton RA, Ohman EM, Giugliano RP, Goodman SG, White HD, Califf RM, Granger CB, Lopes RD. Left Bundle Branch Block in Non-ST-Segment Elevation Acute Coronary Syndromes: Incidence, Angiographic Characteristics, and Clinical Outcomes. J Am Coll Cardiol. 2013; Apr 2;61(13): 1461-3.
Rose JJ, Voora D, Cyr DD, Lucas JE, Zaas AK, Woods CW, Newby LK, Kraus WE, Ginsburg GS. Gene Expression Profiles Link Viral Infection, Platelet Function, and Acute Myocardial Infarction. PLoS One. 2015; Jul 20;10(7).
Rose Jj, Bealmear B, Nedelkoska L, Studzinski D, Lisak RP, Benjamins JA. Cytokines Decrease Expression of Interleukin-6 Signal Transducer and Leptin Receptor in CNS Glia. J Neurosci Res. 2009; Nov 1;87(14): 3098-106.
Rose JJ, Vanhecke TE, McCullough PA. Clinical Manifestations of Subarachnoid Hemorrhage. Rev Cardiovasc Med. 2010; Fall;11(4): 254-63.
Sponsored Research/Activities
Title: Discovering and Developing Recombinant Molecular Scavenging Agents for the Treatment of Carbon Monoxide Induced Cardiovascular Dysfunction
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: K08 HL136857
Start Year: 2018
End Year: 2023
Title: Developing an Antidotal Therapy for Carbon Monoxide Poisoning
Role: Principal Investigator
Funding Agency: Parker B. Francis Foundation
Grant Number: FELLOW
Start Year: 2017
End Year: 2020
Title: Antidote for Inhaled CO Poisoning Based on Mutationally Engineered Neuroglobin
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL125886
Start Year: 2014
End Year: 2018
Notable Achievements
Young Physician-Scientist Award, American Society of Clinical Investigation, 2019
University of Pittsburgh Innovator Award, 2017 & 2019
Parker B. Francis Foundation Fellowship, 2017
Robert M. Rogers Award for Outstanding Scholarly Achievement, 2017
Young Investigator Award, AHA, Resuscitation Meeting, 2016
University of Pittsburgh, Department of Medicine, Best Translational Research Fellow, 2015 & 2016
Robert M. Califf, MD, Medicine Resident Research Award, 2013
American Thoracic Society Abstract Scholarship, 2013
Alpha Omega Alpha, 2010
Consortium of Multiple Sclerosis Research Scholarship, 2007

Division Websites

Cardiology

Endocrinology and Metabolism

Gastroenterology, Hepatology and Nutrition

General Internal Medicine

Geriatric Medicine
Hematology/Oncology

Infectious Diseases

Pulmonary, Allergy and Critical Care Medicine

Renal-Electrolyte

Rheumatology and Clinical Immunology

Contact

Department of Medicine
1218 Scaife Hall
3550 Terrace Street
Pittsburgh, PA 15261
Email:  chairoff@pitt.edu
Phone:  412-648-9636
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