Department of Medicine
Faculty Profiles by Division

Division of Pulmonary, Allergy and Critical Care Medicine

Faculty Profiles

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photo Sally E. Wenzel, MD

Pulmonary, Allergy and Critical Care Medicine

Professor of Medicine

Chair, Department of Environmental & Occupational Health

Director, University of Pittsburgh Asthma and Environmental Lung Health Institute@UPMC

Rachel Carson Chair in Environmental Health

Email:

Phone: 412-624-8300

Contact
Office: UPMC Montefiore Hospital, NW931
3459 Fifth Avenue
Pittsburgh, PA 15213
 
Phone: 412-624-8300
Fax: 412-605-1999
E-mail:
Administrative Assistant:
Kelly Tatone
Email: Kelly.Tatone@pitt.edu
Phone: 412-624-8300
Fax: 412-605-1999
Education and Training
Education
BS, University of Florida, 1978
MD, University of Florida, 1981
Training
Internship in Internal Medicine, Wake Forest Univ Baptist Medical Center, 1982
Residency in Internal Medicine, Wake Forest Univ Baptist Medical Center, 1984
Fellowship In Pulmonary Medicine, Medical College of Virginia, 1986
Research Interest
Dr. Wenzel’s laboratory has focused on understanding both the subtypes of human asthma and the combination of environmental and genetic factors which drive them. Research has been intensive on the role of airway epithelial cells in human disease, given the position of these cells to link the environment with the host. Work encompasses use of large epidemiologic/research databases, including those both local and national, to define patient characteristics and relationships to environmental triggers, but also to include studies of specific human immunology, both in human samples and model systems. Current pathways of interest include those related to environmental and innate lung oxidative stress, as well as their intersections with inflammation, mucins and cell death pathways.
Clinical Interest
Dr. Wenzel has had a passion for understanding and improving the treatment of asthma, in particular severe asthma. She served as Chair of the original ATS workshop and the following ERS-ATS guidelines on severe asthma which developed the definition and approaches to treatment of severe asthma. Dr. Wenzel has been listed as one of Castle Connelly’s top doctors in America for over 15 years. She has worked to promote severe asthma as a disease whose pathogenesis goes beyond issues of non-compliance/adherence. Her studies of asthma phenotypes have led the field in understanding the complexities of asthma and she is internationally recognized for her efforts in this area. To this end, she and her colleagues recently described a new asthmatic disease, called “Asthmatic Granulomatosis”. This severe asthma-like disease responds to alternative medications, beyond steroids.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Ray A, Camiolo M, Fitzpatrick A, Gauthier M, Wenzel SE. Are We Meeting the Promise of Endotypes and Precision Medicine in Asthma?. Physiol Rev. 2020; Jul 1;100(3): 983-1017.
Camiolo MJ, Gauthier M, Kaminski N, Ray A, Wenzel SE. Expression of SARS-CoV-2 Receptor ACE2 and Coincident Host Response Signature Varies by Asthma Inflammatory Phenotype. J Allergy Clin Immunol. 2020; Jun 9:S0091-6749(20): 30828-9.
Zhao J, Dar HH, Deng Y, St Croix CM, Li Z, Minami Y, Shrivastava IH, Tyurina YY, Etling E, Rosenbaum JC, Nagasaki T, Trudeau JB, Watkins SC, Bahar I, Bayir H, VanDemark AP, Kagan VE, Wenzel SE. PEBP1 acts as a rheostat between prosurvival autophagy and ferroptotic death in asthmatic epithelial cells. Proc Natl Acad Sci USA. 2020; Jun 8:201921618: doi:10.1073/pnas.1921618117.Epubaheadofprint.
Wenzel, S, Castro, M, Corren, J, Maspero, J, Wang, L, Zhang, B, Pirozzi, G, Sutherland, ER, Evans, RR, Joish,VN, Eckert, L, Graham, NM, Stahl, N, Yancopoulos, GD, Louis-Tisserand, M, Teper, A. Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting ß2 agonist: a randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial. Lancet. 2016; Jul2;388(10039): 31-44.
Raundhal, M, Morse, C, Khare, A, Oriss, TB, Milosevic, J, Trudeau, J, Huff, R, Pilewski, J, Holguin, F, Kolls, J, Wenzel, S, Ray, P, Ray, A. High IFN-y and low SLPI mark severe asthma in mice and humans. J Clin Invest. 2015; Aug 3;125(8): 3037-50.
Albano, GD, Zhao, J, Etling, EB, Park, SY, Hu, H, Trudeau, JB, Profita, M, Wenzel, SE. IL-13 desensitizes ß2-adrenergic receptors in human airway epithelial cells through a 15-lipoxygenase/G protein receptor kinase 2 mechanism. J Allergy Clin Immunol. 2015; May;135(5): 1144-53.
Modena, BD, Tedrow, JR, Milosevic, J, Bleeker, ER, Meyers, DA, Wu, W, Bar-Joseph, Z, Erzurum, SC, Gason, BM, Busse, WW, Jarjour, NN, Kaminski, N, Wenzel, SE. Gene expression in relation to exhaled nitric oxide identifies novel asthma phenotypes with unique biomolecular pathways. Am J Respir Crit Care Med. 2014; Dec 15;190(12): 1363-72.
Wu, W, Bleecker, E, Moore, W, Busse, WW, Castro, M, Chung, KF, Calhoun, WJ, Erzurum, S, Gaston, B, Israel, E, Curran-Everett, D, Wenzel, SE. Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data. J Allergy Clin Immunol. 2014; May;133(5): 1280-8.
Wenzel, SE, Wang, L, Pirozzi, G. Dupilumab in persistent asthma. N Engl J Med. 2013; Sep 26;369(13): 1276.
Fajt, ML, Gelhaus, SL, Freeman, B, Uvalle, C, Trudeau, JB, Holguin, F, Wenzel, SE. Prostaglandin D2 pathway upregulation: Relation to asthma severity, control and Th2 inflammation. J Allergy Clin Immunol. 2013; Jun;131(6): 1504-1512.
Sponsored Research/Activities
Title: Type-2 or Not Type-2: That is the (Therapeutic) Question
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: UG1 HL139098
Start Year: 2017
End Year: 2023
Title: Severe Asthma Research Program
Role: Principal Investigator
Funding Agency: Penn State/National Heart, Lung, & Blood Institute
Grant Number: U10 HL109086
Start Year: 2012
End Year: 2016
Title: Implications and Stability of Clinical and Molecular Phenotypes of Severe Asthma
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: U10 HL109152
Start Year: 2011
End Year: 2017
Title: Amplification of IL-4Ralpha Signaling Pathways in Human Airways though 15 LO1
Role: Principal Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: R01 AI040600
Start Year: 2010
End Year: 2016
Title: Asthmanet: Phenotypic Influences on Asthma Treatment (ALFA Protocol)
Role: Co-Principal Investigator
Funding Agency: Penn State/National Heart, Lung, & Blood Institute
Grant Number: U10 HL098115
Start Year: 2014
End Year: 2016
Title: Asthmanet: Phenotypic Influences on Asthma Treatment - STICS Protocol
Role: Co-Principal Investigator
Funding Agency: Penn State/National Heart, Lung, & Blood Institute
Grant Number: U10 HL098115
Start Year: 2013
End Year: 2016
Title: Asthmanet: Phenotypic Influences on Asthma Treatment (BARD Protocol)
Role: Co-Principal Investigator
Funding Agency: Penn State/National Heart, Lung, & Blood Institute
Grant Number: U10 HL098115
Start Year: 2013
End Year: 2016
Title: AsthmaNet: Phenotypic Influences on Asthma Treatments - SIENA
Role: Co-Principal Investigator
Funding Agency: Penn State/National Heart, Lung, & Blood Institute
Grant Number: U10 HL098115
Start Year: 2013
End Year: 2016
Title: Improving Asthma Control using Internet-Based Cognitive-Behavioral Treatment for Insomnia
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL131587
Start Year: 2017
End Year: 2021
Title: Mechanisms of Antigen-Induced Tolerance in the Lung
Role: Co-Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: R01 AI048927
Start Year: 2016
End Year: 2021
Title: SPLUNC1 in Severe Asthma
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL125128
Start Year: 2015
End Year: 2019
Title: Toward PanOmic and Personalized Association Study of Complex Diseases - A New Statistical and Computational Paradigm for Personalized Medicine
Role: Co-Investigator
Funding Agency: Carnegie-Mellon University/National Institute of General Medical Science
Grant Number: R01 GM114311
Start Year: 2015
End Year: 2019
Title: Adiposity and Airway Inflammation in HIV-Associated Airway Disease
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R56 HL128134
Start Year: 2015
End Year: 2016
Title: Understanding Severe Asthma Using an Experimental Model
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL113956
Start Year: 2013
End Year: 2017
Title: Th2 Inflammation Promotes Airway Surface Liquid Dehydration
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL112863
Start Year: 2012
End Year: 2017
Title: Clinical Coordinating Center for the Severe Asthma Research Program (SARP)
Role: Co-Investigator
Funding Agency: Penn State/National Heart, Lung, & Blood Institute
Grant Number: U10 HL109086
Start Year: 2011
End Year: 2017
Title: Redox-Derived Pulmonary Anti-Inflammatory Mediators
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL064937
Start Year: 2011
End Year: 2016
Title: Immune Airway-Epithelial Interactions in Steroid-Refractory Severe Asthma - Project 2
Role: Project Leader
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: P01 AI106684
Start Year: 2015
End Year: 2020
Notable Achievements
Ladies Hospital Aid Society Trailblazer Award, 2018
ERS Presidential Award, 2017
ATS Foundation Breathing for LIfe Award, 2016
Member, American Association of Physicians, 2014
ATS Scientific Achievement Award, 2010
Elizabeth Rich Award (ATS), 2005