Department of Medicine
Faculty Profiles by Division

Division of Renal-Electrolyte

Faculty Profiles
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photo Christopher John Passero, MD

Renal-Electrolyte

Clinical Associate Professor of Medicine

Email: passerocj@upmc.edu

Phone: 412-578-9551
Contact
Office: 400.9 Med Arts Bldg
3708 5th Ave
Pittsburgh, PA 15261
 
Phone: 412-578-9551
Fax: 412-578-9286
E-mail: passerocj@upmc.edu
Administrative Assistant:
Maria Simonic
Address: 200 Lothrop St
C1100 - UPMC Presbyterian
Pittsburgh, PA 15213
Email: simonicma@upmc.edu
Phone: 412-802-8652
Education and Training
Education
BA, Brown University, 1998
MD, Brown University, 2002
Training
Internship and Residency, University of Pittsburgh, 2005
Nephrology Fellowship, University of Pittsburgh, 2007
Research Interest
Dr. Christopher Passero is a Clinical Assistant Professor of Medicine in the Renal-Electrolyte Division at the University of Pittsburgh. Clinical interests include caring for patients with chronic kidney disease, kidney disease in the setting of malignancy, and dialysis. He has had research interests involving the post-translational modification of the epithelial sodium channel (ENaC), especially the proteolytic processing of ENaC by the protease plasmin and its potential role in proteinuric kidney disease and edematous states.
Clinical Interest
Dr. Christopher Passero is a Clinical Assistant Professor of Medicine in the Renal-Electrolyte Division at the University of Pittsburgh. Clinical interests include caring for patients with chronic kidney disease, kidney disease in the setting of malignancy, and dialysis. He has had research interests involving the post-translational modification of the epithelial sodium channel (ENaC), especially the proteolytic processing of ENaC by the protease plasmin and its potential role in proteinuric kidney disease and edematous states.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Jindal N, Yadav D, Passero C, Krasinskas A, Craig F, Bastacky S, Liang KV. Membranous nephropathy: a rare renal manifestation of IgG4-related systemic disease. Clin Nephrol. 2012; Apr;77(4): 321-8.
Passero CJ, Mueller GM, Myerburg MM, Carattino MD, Hughey RP, Kleyman TR. TMPRSS4-dependent activation of the epithelial sodium channel requires cleavage of the ?-subunit distal to the furin cleavage site. Am J Physiol Renal Physiol. 2012; Jan 1;302(1): F1-8.
Carattino MD, Passero CJ. Clues to renal sodium retention. Am J Physiol Renal Physiol. 2011; Mar;300(3): F639-40.
Chen J, Myerburg MM, Passero CJ, Winarski KL, Sheng S. External Cu2+ inhibits human epithelial Na+ channels by binding at a subunit interface of extracellular domains. J Biol Chem. 2011; Aug 5;286(31): 27436-46.
Passero CJ, Hughey RP, Kleyman TR. New role for plasmin in sodium homeostasis. Curr Opin Nephrol Hypertens. 2010; 19: 13-9.
Passero CJ, Carattino MD, Kashlan OB, Myerburg MM, Hughey RP, Kleyman TR. Defining an inhibitory domain in the gamma subunit of the epithelial sodium channel. Am J Physiol Renal Physiol. 2010; Oct;299(4): F854-61.
Passero CJ, Okumura S, Carattino MD. Conformational changes associated with proton-dependent gating of ASIC1a. J Biol Chem. 2009; 284: 36473-81.
Carattino MD, Passero CJ, Steren CA, Maarouf AB, Pilewski JM, Myerburg MM, Hughey RP, Kleyman TR. Defining an inhibitory domain in the alpha-subunit of the epithelial sodium channel. Am J Physiol Renal Physiol. 2008; 294: 47-52.
Passero CJ, Mueller GM, Rondon-Berrios H, Tofovic SP, Hughey RP, Kleyman TR. Plasmin activates epithelial Na+ channels by cleaving the gamma subunit. J Biol Chem. 2008; 283: 36586-91.
Notable Achievements
Pittsburgh Top Doctors, 2022

Division Websites

Cardiology

Endocrinology and Metabolism

Gastroenterology, Hepatology and Nutrition

General Internal Medicine

Geriatric Medicine
Hematology/Oncology

Infectious Diseases

Pulmonary, Allergy and Critical Care Medicine

Renal-Electrolyte

Rheumatology and Clinical Immunology

Contact

Department of Medicine
1218 Scaife Hall
3550 Terrace Street
Pittsburgh, PA 15261
Email:  chairoff@pitt.edu
Phone:  412-648-9636
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