Department of Medicine
Faculty Profiles by Division

Division of Renal-Electrolyte

Faculty Profiles

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photo David Rothstein, MD


Pittsburgh Steelers Chair in Transplantation

Professor of Surgery, Medicine, and Immunology


Phone: 412-648-7154

Office: 200 Lothrop Street
Biomedical Science Tower, W1542
Pittsburgh, PA 15260
Phone: 412-648-7154
Education and Training
BA, University at Buffalo
MD, The University of Pennsylvania School of Medicine
Research Interest
My laboratory studies immunoregulation and tolerance in allograft and autoimmune models. We have used reagents that and promote tolerance by targeting specific molecules. By studying their basic mechanism(s) of action we can identify new immunoregulatory pathways.
For my complete bibliography, Click Here.
Selected Publications:
Li, H., Demetris, A.J., McNiff, J., Matte-Martone, C., Tan, H.S., Rothstein, D.M., Lakkis, F.G., Shlomchik, W.D. Profound depletion of host conventional dendritic cells, plasmacytoid dendritic cells, and B cells does not prevent graft-versus-host disease induction. Journal of Immunology. 2012; 188(8): 3804-11.
Walch, J.M., Zeng, Q., Li,Q., Oberbarnscheidt, M.H., Hoffman, R.A., Williams, A.L., Rothstein, D.M., Schlomchik, W.D., Kim, J.V., Camirand, G., Lakkis, F.G. Cognate antigen directs CD8+ T cell migration to vascularized transplants. Journal of Clinical Investigation. 2013; 123(6): 2663-71.
Cherukirr, A., Rothstein, D.M., Clark, B., Carter, C.R., Davidson, A., Hernandez, Fuentes, M., Hewitt, E., Salama, A.D., Baker, R.J. Immunologic human renal allograft injury associates with an altered IL-10/TNF-a expression ratio in regulatory B cells. Journal of the American Society of Nephrology. 2014; 25(7): 1575-85.
Vergani, A., Gatti, F., Lee, K.M., D'Addio, F., Tezza, S., Chin, M., Bassi, R., Tian, Z., Wu, E., Maffi, P., Ben Nasr, M., Kim, J.I., Secchi, A., Markmann, J.F., Rothstein, D.M., Turka, L.A., Sayegh, M.H., Fiorina, P. TIM4 Regulates the Anti-Islet Th2 Alloimmune Response. Cell Transplant. 2015; 24(8): 1599-614.
Oberbarnscheidt, M.H., Zeng, Q., Li, Q., Dai, H., Williams, A.L., Shlomchik, W.D., Rothstein, M.D., Lakkis, F.G. Non-self recognition by monocytes initiates allograft rejection. Journal of Clinical Investigation. 2014; 124(8): 3579-89.
Camirand, G., Wang, Y., Lu, Y., Wan, Y.Y., Lin, Y., Deng, S., Guz, G., Perkins, D.L., Finn, P.W., Farber, D.L., Flavell, R.A., Sclomchik, W.D., Lakkis, F.G., Rudd, C.E., Rothstein, D.M. CD45 ligation expands Tregs by promoting interactions with DCs. Journal Clinical Investigation. 2014; 124(10): 4603-13.
Kim, J.I., Rothstein, D.M., Markmann, J.F. Role of B cells in tolerance induction. Current Opinion in Organ Transplantation. 2015; 20(4): 369-75.
Rothstein, D.M., Camirand, G. New insights into the mechanisms of Treg function. Current Opinion in Organ Transplantation. 2015; 20(4): 376-84.
Grossman, T.H., Starosta, A.L., Fyfe, C., O;Brien, W., Rothstein, D.M., Mikolajka, A., Wilson, D.N., Sutcliffe, J.A. Erratum for Grossman et al., target- and resistance-based mechanistic studies with TP-434, a novel fluorocycline antibiotic. Antimicrobial Agents and Chemotherapy. 2015; 59(9): 5870.
Rothstein, D.M. Rifamycins, Alone and in Combination. Cold Spring Harbor Perspectives in Medicine. 2016; 6(7): a027011.