Department of Medicine
Faculty Profiles by Division

Division of Renal-Electrolyte

Faculty Profiles
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photo Arohan R. Subramanya, MD

Renal-Electrolyte

Associate Professor of Medicine

Associate Professor of Cell Biology

Staff Physician, VA Pittsburgh Healthcare System

Graduate Faculty, Cell Biology & Molecular Physiology Program

Graduate Faculty, Integrative Systems Biology Program

Email: ars129@pitt.edu

Phone: 412-624-3669
Contact
Office: S826 Scaife Hall
3550 Terrace Street
Pittsburgh, PA 15261
 
Phone: 412-624-3669
Fax:
E-mail: ars129@pitt.edu
Administrative Assistant:
Maria Delesio
Address: S974 - Scaife Hall
3500 Terrace St
Pittsburgh, PA 15261
Email: mcd112@pitt.edu
Phone: 412-383-9753
Education and Training
Education
BS, University of Michigan, 1993
M.D., Case Western Reserve University, 1998
Training
Internship and Residency, Oregon Health and Science University, 2001
Nephrology Fellowship, Oregon Health and Science University, 2005
AHA Postdoctoral Fellowship, Oregon Health and Science University, 2005
NIH Postdoctoral Fellowship, University of Maryland, 2007
Research Interest
The goal of Dr. Subramanya’s research is to define and understand new molecular pathways that coordinate sodium, chloride, and potassium transport in the kidney and other organs. His work has provided insights into the pathogenesis of renal salt wasting nephropathies, and identified novel mechanisms
involved in the regulation of cell volume, blood pressure, and potassium balance.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Subramanya, A. R., Boyd-Shiwarski, C. R., Griffiths, S. E., Beacham, R. T., Norrell, L., Morrison, D. E., Wang, J., Mann, J., Tennant, W., Anderson, E. N., Franks, J., Calderon, M., Connolly, K. A., Cheema, M. U., Weaver, C. J., Nkashama, L. J., Weckerly, C. C., Querry, K. E., Pandey, U. B., Shiwarski, D. J. WNK kinases sense molecular crowding and rescue cell volume via phase separation. Cell - Science Direct. 2022; 185(24): 4488-4506.
Subramanya AR, Liu J, Ellison DH, Wade JB, Welling PA. WNK4 diverts the thiazide-sensitive NaCl cotransporter to the lysosome and stimulates AP-3 interaction. Journal of Biological Chemistry. 2009; 284: 18471-80.
Rozansky DJ, Cornwall T, Subramanya AR, Feng YF, David LL, Zhu X, Yang CL, Ellison DH. Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway. Journal of Clinical Investigation. 2009; In Press.
Sponsored Research/Activities
Title: Regulation of Renal WNK Signaling in Intercalated Cells
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01
Start Year: 2019
End Year: 2024
Title: Epithelial Transport Group Sessions at Experimental Biology 2017
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R13 DK113774
Start Year: 2017
End Year: 2018
Title: Characterization and Control of the Renal WNK1 Signaling Pathway
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK098145
Start Year: 2014
End Year: 2019
Title: Pittsburgh Center for Kidney Research (Pilot Subramanya Lab)
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: P30 DK079307
Start Year: 2013
End Year: 2018
Title: Genetic and Functional Analysis of Hypertension Susceptibility Genes
Role: Principal Investigator
Funding Agency: University of Maryland/National Heart, Lung, & Blood Institute
Grant Number: R01 HL0888120
Start Year: 2013
End Year: 2018
Title: Impact of Sleep on Chronobiology of Micturition
Role: Co-Investigator
Funding Agency: National Institute of Aging
Grant Number: R21 AG050892
Start Year: 2016
End Year: 2018
Title: Maturation of K Transport in the Distal Nephron
Role: Co-Investigator
Funding Agency: Mt. Sinai Medical Center/National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK038470
Start Year: 2015
End Year: 2020
Title: The Role of Na/H Exchanger in Cerebral Ischemia
Role: Molecular Biologist
Funding Agency: National Institute of Neurological Disorder & Stroke
Grant Number: R01 NS048216
Start Year: 2016
End Year: 2021

Division Websites

Cardiology

Endocrinology and Metabolism

Gastroenterology, Hepatology and Nutrition

General Internal Medicine

Geriatric Medicine
Hematology/Oncology

Infectious Diseases

Pulmonary, Allergy and Critical Care Medicine

Renal-Electrolyte

Rheumatology and Clinical Immunology

Contact

Department of Medicine
1218 Scaife Hall
3550 Terrace Street
Pittsburgh, PA 15261
Email:  chairoff@pitt.edu
Phone:  412-648-9636
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