Department of Medicine
Faculty Profiles by Division

Division of Renal-Electrolyte

Faculty Profiles

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photo Roderick J. Tan, MD, PhD

Renal-Electrolyte

Email: tanrj@upmc.edu

Phone: 412-624-4008

Contact
Office: S976.1 Scaife Hall
3550 Terrace Street
Pittsburgh, PA 15261
 
Phone: 412-624-4008
Fax: 412-647-6222
E-mail: tanrj@upmc.edu
Administrative Assistant:
Maria Delesio
Address: S974 - Scaife Hall
3500 Terrace St
Pittsburgh, PA 15261
Email: mcd112@pitt.edu
Phone: 412-383-9753
Education and Training
Education
BS, Georgetown University, 1999
M.D., University of Pittsburgh, 2007
Ph.D., University of Pittsburgh, 2007
Training
Residency, Medicine, University of Pittsburgh Medical Center, 2010
Fellowship, Renal-Electrolyte, University of Pittsburgh Medical Center, 2012
Research Interest
My lab is interested in identifying the molecular mechanisms that contribute to the development of acute kidney injury and chronic kidney disease. We utilize a combination of in vivo animal models (experimental models of disease, conditional knockout mice) and in vitro (tubular and podocyte cell culture) methods. Our research has revealed that the Keap1/Nrf2 pathway protects against AKI-to-CKD progression but may also have a paradoxical role in promoting proteinuria and podocyte/glomerular injury. We are studying the role of MCP-1 and Wnt/beta-catenin on proteinuria and kidney fibrosis. We are collaborating on projects to identify and characterize microvascular rarefaction in the kidney with super-resolution ultrasound in both animal models and human subjects. Our overall goal is to improve the understanding, diagnosis, and treatment of kidney disease using a translational bench-to-bedside approach.
Clinical Interest
Glomerular Disease
Acute Kidney Injury
Microvascular Rarefaction
Amyloidosis (https://cardiacamyloidosis.pitt.edu/)
Educational Interest
Medical School Teaching
Graduate School Teaching
Publications
For my complete bibliography, Click Here.
Selected Publications:
Tan RJ, Zhou D, Zhou L, Liu Y. Wnt/ß-catenin signaling and kidney fibrosis. Kidney International Supplements. 2014; 4(1): 84-90.
Tan RJ, Zhou D, Xiao L, Zhou L, Li Y, Bastacky SI, Oury TD, Liu Y. Extracellular Superoxide Dismutase Protects against Proteinuric Kidney Disease. Journal of the American Society of Nephrology : JASN. 2015; 26(10): 2447-59.
Tan RJ, Li Y, Rush BM, Cerqueira DM, Zhou D, Fu H, Ho J, Beer Stolz D, Liu Y. Tubular injury triggers podocyte dysfunction by ß-catenin-driven release of MMP-7. JCI Insight. 2019; 4(24): e122399.
Rush BM, Small SA, Stolz DB, Tan RJ. An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney. J Vis Exp. 2018; (141): e58162.
Jobbagy S, Tan RJ. Nitrolipids in kidney physiology and disease. Nitric Oxide. 2018; S1089-8603(18): 30006-5.
Tan RJ, Chartoumpekis DV, Rush BM, Zhou D, Fu H, Kensler TW, Liu Y. Keap1 hypomorphism protects against ischemic and obstructive kidney disease. Scientific Reports. 2016; 6: 36185.
Tan RJ, Zhou L, Zhou D, Lin L, Liu Y. Endothelin receptor a blockade is an ineffective treatment for adriamycin nephropathy. PLoS One. 2013; 8(11): e79963.
Tan RJ, Fattman CL, Niehouse LM, Toboleweski JM, Hanford LE, Li Q, Monzon FA, Parks WC, Oury TD. Matrix metalloproteinases promote inflammation and fibrosis in asbestos-induced lung injury in mice. American Journal of Respiratory Cell and Molecular Biology. 2006; 35(3): 289-97.
Tan RJ, Lee JS, Manni ML, Fattman CL, Tobolewski JM, Zheng M, Kolls JK, Martin TR, Oury TD. Inflammatory cells as a source of airspace extracellular superoxide dismutase after pulmonary injury. American Journal of Respiratory Cell and Molecular Biology. 2006; 34(2): 226-32.
Tan RJ, Fattman CL, Watkins SC, Oury TD. Redistribution of pulmonary EC-SOD after exposure to asbestos. Journal of Applied Physiology. 2004; 97(5): 2006-13.
Sponsored Research/Activities
Title: Unraveling Podocyte Injury and Repair in Chronic Kidney Disease
Role: Principal Investigator
Funding Agency: Samuel and Emma Winters Foundation / Samuel and Emma Winters Foundation
Grant Number: RES
Start Year: 2019
End Year: 2020
Title: Tubular to Glomerular Crosstalk in Proteinuric Chronic Kidney Disease
Role: Principal Investigator
Funding Agency: American Society of Nephrology
Grant Number: RES
Start Year: 2018
End Year: 2020
Title: Super-Resolution Ultrasound for Assessment of Kidney Vasculature
Role: Principal Investigator
Funding Agency: National Kidney Foundation
Start Year: 2018
End Year: 2019
Title: Oxidative Stress in Chronic Kidney Disease
Role: Principal Investigator
Funding Agency: American Heart Association-National
Grant Number: FELLOW
Start Year: 2013
End Year: 2018
Title: Pittsburgh Center for Kidney Research -PILOT
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: P30 DK079307
Start Year: 2013
End Year: 2018
Notable Achievements
Young Investigator Award, Society for Free Radical Biology and Medicine, 2004
Lawrence Reardon Professionalism Award, Internal Medicine Residency Program, UPMC, 2010
Frank J. Bruns Teaching Award, 2012
Young Physician-Scientist Award, The American Society for Clinical Investigation, 2016
Excellence in Education Award, Small Group (PBL) Facilitator for Renal-Electrolyte Course, 2020