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Division of Renal-Electrolyte
Faculty Profiles
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Xueping Wang, PhD
Renal-Electrolyte
Instructor
Email:
xuw30@pitt.edu
Phone: 412-648-9277
Contact
Office:
3550 Terrace St
S834
Pittsburgh, PA 15261
Phone:
412-648-9277
Fax:
E-mail:
xuw30@pitt.edu
Education and Training
Education
B.A., Anhui Normal University, China, 2010
Ph.D., The University of Science and Technology of China, 2016
Research Interest
The epithelial sodium channel (ENaC) is expressed in several Na+ transporting epithelia, including colon, lung and kidney. Dr. Wang’s research efforts are focused on investigating ENaC regulation by bile acids, which are highly elevated in some advanced liver diseases. Her achievements showed that bile acids regulate ENaC in vitro, ex vitro and in vivo. She is currently using different mouse models to illustrate bile acids pathophysiological regulation mechanism. She is also seeking a structurally based understanding of ENaC d subunit functional properties.
Educational Interest
Her PhD research mainly focused on structural and functional studies of cyanobacterial proteins. She determined structures of target proteins using X-ray crystallography. She also investigated their biological function using HPLC, ITC, SPR, etc.
Publications
Selected Publications:
Kashlan, OB, Wang, XP, Sheng, S, Kleyman, TR. Epithelial Na+ Channels Function as Extracellular Sensors.
Comprehensive Physiology
. 2024; 14(2): 5407-5447.
Wang, XP, Srinivasan, P, Hamdaoui, ME, Ruxandra-Carvunis, A, Grytz, RG, Kashlan, OB. Varying selection pressure for a Na+ sensing site in epithelial Na+ channel subunits reflect divergent roles in Na+ homeostasis.
bioRxiv
. 2024.
Wang, XP, Mutchler, SM, Carrisoza-Gáytan, R, Al-Bataineh, M, Baty, CJ, Vandevender, A, Srinivasan, P, Tan, RJ, Jurczak, MJ, Satlin, LM, Kashlan, OB. Mineralocorticoid receptor-independent activation of ENaC in bile duct ligated mice.
bioRxiv
. 2023.
Wang, XP, Tomilin, V, Nickerson, AJ, Tian R, Ertem, M, McKernan, A, Lei, X, Pochynyuk, O, Kashlan, OB. Bile acids regulate the epithelial Na+ channel in native tissues through direct binding at multiple sites.
The Journal of Physiology
. 2022; 600(21): 4695-4711.
Wang, XP, Balchak, DM, Gentilecore, C, Clark, NL, Kashlan, OB. Activation by cleavage of the epithelial Na+ channel a and ? subunits independently coevolved with the vertebrate terrestrial migration.
eLife
. 2022; 11: e75796.
Wang Xue-Ping, Im Seohyun Janice, Balchak Deidra M., Montalbetti Nicolas, Carattino Marcelo D., Ray Evan C., Kashlan Ossama B. Murine epithelial sodium (Na +) channel regulation by biliary factors.
J Biol Chem:
. 2019; 294(26): 10182-10193.
Blobner Brandon M., Wang Xue-Ping, Kashlan Ossama B. Conserved cysteines in the finger domain of the epithelial Na+ channel a and ? subunits are proximal to the dynamic finger-thumb domain interface.
J Biol Chem
. 2018; 293(13): 4928-4939.
Jiang Yong-Liang, Wang Xue-Ping, Sun Hui, Han Shu-Jing, Li Wei-Fang, Cui Ning, Lin Gui-Ming, Zhang Ju-Yuan, Cheng Wang, Cao Dong-Dong, Zhang Zhi-Yong, Zhang Cheng-Cai, Chen Yuxing, Zhou Cong-Zhao. Coordinating carbon and nitrogen metabolic signaling through the cyanobacterial global repressor NdhR.
Proc Natl Acad Sci U S A
. 2018; 115(2): 403-408.
