Department of Medicine
Faculty Profiles by Division

Division of Rheumatology and Clinical Immunology

Faculty Profiles

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photo Mandy J McGeachy, PhD

Rheumatology

Associate Professor of Medicine

Email: mmcgeach@pitt.edu

Contact
Office: 3500 Terrace Street
BST South, S719
Pittsburgh, PA 15261
 
E-mail: mmcgeach@pitt.edu
Administrative Assistant:
Linda Sadej
Address: 3500 Terrace Street
Biomedical Science Tower South, 7th Floor
Pittsburgh, PA 15261
Email: sadej@pitt.edu
Phone: 412-383-8123
Fax: 412-383-8753
Education and Training
Education
BSc (Immunology), University of Glasgow, Scotland, UK, 2001
PhD (Immunology), University of Edinburgh, Scotland, UK, 2005
Training
Postdoc, Schering-Plough Biopharma/DNAX, 2009
Senior Scientist/Associate Principal Scientist, Merck Research Labs, 2011
Research Interest
Th17 cells cause chronic tissue inflammation in autoimmune diseases like psoriasis, multiple sclerosis and Crohn’s disease. However, Th17 cells and other ‘type-17’ cells provide vital protection against commensals and opportunistic pathogens at barrier surfaces, and also aid in wound repair. Many of these effects are achieved through IL-17. Perhaps due to these dual functions of Th17 cells, therapies targeted towards the IL-17 pathway are highly efficacious in some diseases, but have had mixed results in others. The McGeachy lab studies how inflammatory Th17 cells are generated, regulated and mediate their effects through IL-17 in different tissues, with the goal of determining the best approaches to modulate Th17-driven pathology while conserving the beneficial protective roles of Th17 cells.
Key questions being addressed:
1) Molecular mechanisms that regulate Th17 differentiation in humans, with a focus on the interplay between costimulatory and cytokine signaling;
2) Functional regulators of in vivo Th17 effector cell pathogenicity;
3) Regulation of Th17 migration in different tissues;
4) Th17:tissue interactions that lead to stromal cell remodeling during chronic inflammation .
Publications
For my complete bibliography, Click Here.
Selected Publications:
Majumder S. IL-17 metabolically reprograms activated fibroblastic reticular cells for proliferation and survival. Nature Immunology. 2019.
Hernandez Mir G. The Alzheimer’s Disease-associated protein BACE1 modulates T cell activation and Th17 function. Journal of Immunology. 2019.
Shankar Revu, Jing Wu, Matthew Henkel, Natalie Rittenhouse, Ashley Menk, Greg Delgoffe, Amanda Poholek, Mandy McGeachy. IL-23 and IL-1b Drive Human Th17 Cell Differentiation and Metabolic Reprogramming in Absence of CD28 Costimulation. Cell Reports. 2018.
Hernandez-Mir, G, McGeachy, MJ. CD73 is expressed by inflammatory Th17 cells in experimental autoimmune encephalomyelitis but does not limit differentiation or pathogenesis. PLoS One. 2017.
Fang, D, Garg, AV, Kosar, K, Majumder, S, Kugler, DG, Mir, GH, Maggio, M, Henkel, M, Lacy-Hilbert, A, McGeachy, MJ. Inflammatory Th17 Cells Express Integrin avß3 for Pathogenic Function. Cell Reports. 2016; 16(5): 1339-1351.
Singh, D, Henkel, M, Sendon, B, Feng, J, Fabio, A, Metes, D, Moreland, LW, McGeachy, MJ. Analysis of CXCR5+Th17 cells in relation to disease activity and TNF inhibitor therapy in Rheumatoid Arthritis. Scientific Reports. 2016; 6: 39474.
Sponsored Research/Activities
Title: Generation of a 'humanized' CD28 mouse for in vivo studies of role of costimulation during Th17 development
Role: Principal Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: R03 AI144229
Start Year: 2019
End Year: 2020
Title: Regulation of Th17 Functions in Autoimmune CNS Inflammation
Role: Principal Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: R01 AI110822
Start Year: 2014
End Year: 2019
Title: IL-23 STAT3 Driven Oral Immune Responses to Candida Albicans
Role: Principal Investigator
Funding Agency: National Institute of Dental/Craniofacial Research
Grant Number: R01 DE023815
Start Year: 2013
End Year: 2018
Title: Host and Fugal Regulation of Type 17 Immunity to Oral Candidiasis
Role: Co-Investigator
Funding Agency: National Institute of Dental/Craniofacial Research
Grant Number: R01 DE022550
Start Year: 2017
End Year: 2022
Title: IL-17 Isoforms in Organ Specific Autoimmunity
Role: Co-Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: R21 AI128991
Start Year: 2016
End Year: 2018
Title: UPITT Rheumatoid Arthritis Combined Center (UPITT RACC)
Role: Co-Investigator
Funding Agency: National Institute of Arthristis, Muscoskel, & Skin Disease
Grant Number: UH2 AR067685
Start Year: 2014
End Year: 2017
Title: IL-17 Receptor Signaling in the Oral Mucosa (Administrative Supplement)
Role: Co-Investigator
Funding Agency: National Institute of Dental/Craniofacial Research
Grant Number: R01 DE022550
Start Year: 2013
End Year: 2017
Title: Rheumatoid Arthritis Comparative Effectiveness Research (RACER) Longitudinal Extension Study
Role: Co-Investigator
Funding Agency: Genentech, Inc.
Start Year: 2010
End Year: 2016
Notable Achievements
Member, American Association of Immunologists, 2011-present
Member, American College of Rheumatology, 2012-present
Member, International Cytokine and Interferon Society, 2013-present
International Cytokine and Interferon Society Young Investigator, 2013
Editorial Board Member, Cytokine, 2014-present
Editorial Board Member, Scientific Reports, 2015-present